CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006810
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Acetate kinase 
Protein Synonyms/Alias
 Acetokinase 
Gene Name
 ackA 
Gene Synonyms/Alias
 BSU29470 
Created Date
 July 27, 2013 
Organism
 Bacillus subtilis (strain 168) 
NCBI Taxa ID
 224308 
Lysine Modification
Position
Peptide
Type
References
78LTEFGIIKDLNEIDGacetylation[1]
Reference
 [1] The acetylproteome of Gram-positive model bacterium Bacillus subtilis.
 Kim D, Yu BJ, Kim JA, Lee YJ, Choi SG, Kang S, Pan JG.
 Proteomics. 2013 May;13(10-11):1726-36. [PMID: 23468065] 
Functional Description
 Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction. Appears to favor the formation of acetate. Involved in the secretion of excess carbohydrate. 
Sequence Annotation
 NP_BIND 206 210 ATP (By similarity).
 NP_BIND 281 283 ATP (By similarity).
 NP_BIND 329 333 ATP (By similarity).
 ACT_SITE 146 146 Proton donor/acceptor (By similarity).
 METAL 8 8 Magnesium (By similarity).
 METAL 382 382 Magnesium (By similarity).
 BINDING 15 15 ATP (By similarity).
 BINDING 89 89 Substrate (By similarity).  
Keyword
 ATP-binding; Complete proteome; Cytoplasm; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 395 AA 
Protein Sequence
MSKIIAINAG SSSLKFQLFE MPSETVLTKG LVERIGIADS VFTISVNGEK NTEVTDIPDH 60
AVAVKMLLNK LTEFGIIKDL NEIDGIGHRV VHGGEKFSDS VLLTDETIKE IEDISELAPL 120
HNPANIVGIK AFKEVLPNVP AVAVFDTAFH QTMPEQSYLY SLPYEYYEKF GIRKYGFHGT 180
SHKYVTERAA ELLGRPLKDL RLISCHLGNG ASIAAVEGGK SIDTSMGFTP LAGVAMGTRS 240
GNIDPALIPY IMEKTGQTAD EVLNTLNKKS GLLGISGFSS DLRDIVEATK EGNERAETAL 300
EVFASRIHKY IGSYAARMSG VDAIIFTAGI GENSVEVRER VLRGLEFMGV YWDPALNNVR 360
GEEAFISYPH SPVKVMIIPT DEEVMIARDV VRLAK 395 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0008776; F:acetate kinase activity; IEA:HAMAP.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0000287; F:magnesium ion binding; IEA:HAMAP.
 GO:0006085; P:acetyl-CoA biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0006082; P:organic acid metabolic process; IEA:InterPro. 
Interpro
 IPR004372; Ac/Proprionate_kinase.
 IPR000890; Aliphatic_acid_kin_short-chain.
 IPR023865; Aliphatic_acid_kinase_CS. 
Pfam
 PF00871; Acetate_kinase 
SMART
  
PROSITE
 PS01075; ACETATE_KINASE_1
 PS01076; ACETATE_KINASE_2 
PRINTS
 PR00471; ACETATEKNASE.