UniProt Accession

 COAD_ECOLI; P0A6I6; P23875; Q2M7U8 

Genbank Protein ID

 M60670; M86305; U00039; U00096; AP009048 

Genbank Nucleotide ID

 AAA24044.1; AAA03746.1; AAB18611.1; AAC76658.1; BAE77658.1 

Protein Name

 Phosphopantetheine adenylyltransferase 

Protein Synonyms/Alias

 Dephospho-CoA pyrophosphorylase; Pantetheine-phosphate adenylyltransferase; PPAT 

Gene Name

 coaD 

Gene Synonyms/Alias

 kdtB; yicA; b3634; JW3609 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
42	AIAASPSKKPMFTLE	acetylation	[1]
43	IAASPSKKPMFTLEE	acetylation	[1]
133	FISSSLVKEVARHQG	acetylation	[1]
157	VHQALMAKLA*****	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. 

Sequence Annotation

  

Keyword

 3D-structure; ATP-binding; Coenzyme A biosynthesis; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleotide-binding; Nucleotidyltransferase; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 159 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004595; F:pantetheine-phosphate adenylyltransferase activity; IDA:EcoCyc.
 GO:0015937; P:coenzyme A biosynthetic process; IDA:EcoCyc. 

Interpro

 IPR004821; Cyt_trans-like.
 IPR001980; LPS_biosynth.
 IPR014729; Rossmann-like_a/b/a_fold. 

Pfam

 PF01467; CTP_transf_2 

SMART

  

PROSITE

  

PRINTS

 PR01020; LPSBIOSNTHSS.