CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017954
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger and SCAN domain-containing protein 18 
Protein Synonyms/Alias
 Zinc finger protein 447 
Gene Name
 ZSCAN18 
Gene Synonyms/Alias
 ZNF447 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
118AQYPESCKKAASLVEubiquitination[1]
217ANTEQKLKSFPEDPQubiquitination[1]
240DPAEENLKSYRKLLLubiquitination[1]
244ENLKSYRKLLLWGYQubiquitination[1]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
 May be involved in transcriptional regulation. 
Sequence Annotation
 DOMAIN 49 131 SCAN box.
 ZN_FING 413 435 C2H2-type 1.
 ZN_FING 441 463 C2H2-type 2.  
Keyword
 Alternative splicing; Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 510 AA 
Protein Sequence
MLPLEKAFAS PRSSPAPPDL PTPGSAAGVQ QEEPETIPER TPADLEFSRL RFREFVYQEA 60
AGPHQTLARL HELCRQWLMP EARSKEQMLE LLVLEQFLGI LPDKVRPWVV AQYPESCKKA 120
ASLVEGLADV LEEPGMLLGS PAGSSSILSD GVYERHMDPL LLPGELASPS QALGAGEIPA 180
PSETPWLSPD PLFLEQRRVR EAKTEEDGPA NTEQKLKSFP EDPQHLGEWG HLDPAEENLK 240
SYRKLLLWGY QLSQPDAASR LDTEELRLVE RDPQGSSLPE GGRRQESAGC ACEEAAPAGV 300
LPELPTEAPP GDALADPPSG TTEEEEEQPG KAPDPQDPQD AESDSATGSQ RQSVIQQPAP 360
DRGTAKLGTK RPHPEDGDGQ SLEGVSSSGD SAGLEAGQGP GADEPGLSRG KPYACGECGE 420
AFAWLSHLME HHSSHGGRKR YACQGCWKTF HFSLALAEHQ KTHEKEKSYA LGGARGPQPS 480
TREAQAGARA GGPPESVEGE APPAPPEAQR 510 
Gene Ontology
 GO:0005634; C:nucleus; IBA:RefGenome.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0000981; F:sequence-specific DNA binding RNA polymerase II transcription factor activity; IBA:RefGenome.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0016032; P:viral reproduction; IEA:InterPro. 
Interpro
 IPR008916; Retrov_capsid_C.
 IPR003309; Tscrpt_reg_SCAN.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF02023; SCAN
 PF00096; zf-C2H2 
SMART
 SM00431; SCAN
 SM00355; ZnF_C2H2 
PROSITE
 PS50804; SCAN_BOX
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS