CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011253
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cyclin-dependent kinase 18 
Protein Synonyms/Alias
 Cell division protein kinase 18; PCTAIRE-motif protein kinase 3; Serine/threonine-protein kinase PCTAIRE-3 
Gene Name
 Cdk18 
Gene Synonyms/Alias
 Pctaire3; Pctk3 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
99LENPGLPKPLTRMSRubiquitination[1]
123GKLETYVKLDKLGEGubiquitination[1]
150TENLVALKEIRLEHEubiquitination[1]
172IREVSLLKDLKHANIubiquitination[1]
244KILHRDLKPQNLLINubiquitination[1]
257INERGELKLADFGLAubiquitination[1]
428LKEIQLQKDPGYRGLubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 May play a role in signal transduction cascades in terminally differentiated cells. 
Sequence Annotation
 DOMAIN 121 402 Protein kinase.
 NP_BIND 127 135 ATP (By similarity).
 ACT_SITE 242 242 Proton acceptor (By similarity).
 BINDING 150 150 ATP (By similarity).
 MOD_RES 12 12 Phosphoserine (By similarity).
 MOD_RES 51 51 Phosphoserine (By similarity).
 MOD_RES 66 66 Phosphoserine.
 MOD_RES 75 75 Phosphoserine (By similarity).
 MOD_RES 109 109 Phosphoserine (By similarity).  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 451 AA 
Protein Sequence
MNKMKNFKRR LSLSVPRPET IEESLAEFTE QFNQLHTQTN EDGTDEPEQL SPGMQYQQRQ 60
NQRRFSMEDL NKRLSLPMDI RLPQEFLQKL QLENPGLPKP LTRMSRRASL SDIGFGKLET 120
YVKLDKLGEG TYATVFKGRS KLTENLVALK EIRLEHEEGA PCTAIREVSL LKDLKHANIV 180
TLHDLIHTDR SLTLVFEYLD SDLKQYLDHC GNLMNMHNVK IFMFQLLRGL AYCHHRKILH 240
RDLKPQNLLI NERGELKLAD FGLARAKSVP TKTYSNEVVT LWYRPPDVLL GSTEYSTPID 300
MWGVGCILYE MATGKPLFPG STVKEELHLI FRLLGTPTEE SWPGVTSISE FRAYNFPRYL 360
PQPLLSHAPR LDTEGINLLS SLLLYESKSR MSAEAALNHP YFQSLGDRVH QLHDTASIFS 420
LKEIQLQKDP GYRGLAFQHP GRGKSRRQSI F 451 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004693; F:cyclin-dependent protein serine/threonine kinase activity; IEA:EC. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00069; Pkinase 
SMART
 SM00220; S_TKc 
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS