| Tag | Content |
|---|
| CPLM ID | CPLM-014336 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Cytidine monophosphate-N-acetylneuraminic acid hydroxylase |
Protein Synonyms/Alias | CMP-N-acetylneuraminic acid hydroxylase; CMP-N-acetylneuraminate monooxygenase; CMP-Neu5Ac hydroxylase; CMP-NeuAc hydroxylase |
Gene Name | Cmah |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 5 | ***MMDRKQTAETLL | ubiquitination | [1] | | 36 | FRNKTTGKEYILYKE | ubiquitination | [1] | | 63 | HQGGLFMKDIEDLDG | ubiquitination | [1] | | 328 | GKFTEEWKAQFIKAE | ubiquitination | [1] | | 333 | EWKAQFIKAERRKLL | ubiquitination | [1] | | 343 | RRKLLNYKAQLVKDL | ubiquitination | [1] | | 348 | NYKAQLVKDLQPRIY | ubiquitination | [1] | | 370 | VESHPSDKYIKETNT | ubiquitination | [1] | | 378 | YIKETNTKNDPNQLN | ubiquitination | [1] | | 390 | QLNNLIRKNSDVVTW | ubiquitination | [1] | | 428 | VEPPEGTKIYKDSWD | ubiquitination | [1] | | 570 | PLTPPNWKSFLMHCD | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Catalyzes the conversion of CMP-N-acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N- glycolylneuraminic acid (CMP-Neu5Gc), a sialic acid abundantly expressed at the surface of many cells, except in brain. |
Sequence Annotation | DOMAIN 14 112 Rieske.
METAL 54 54 Iron-sulfur (2Fe-2S) (By similarity).
METAL 56 56 Iron-sulfur (2Fe-2S); via pros nitrogen
METAL 75 75 Iron-sulfur (2Fe-2S) (By similarity).
METAL 78 78 Iron-sulfur (2Fe-2S); via pros nitrogen |
Keyword | 2Fe-2S; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Electron transport; Endoplasmic reticulum; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Reference proteome; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 577 AA |
Protein Sequence | MMDRKQTAET LLTLSPAEVA NLKEGINFFR NKTTGKEYIL YKEKDHLKAC KNLCKHQGGL 60
FMKDIEDLDG RSVKCTKHNW KLDVSTMKYI NPPGSFCQDE LVIEMDENNG LSLVELNPPN 120
PWDSDPRSPE ELAFGEVQIT YLTHACMDLK LGDKRMVFDP WLIGPAFARG WWLLHEPPSD 180
WLERLCKADL IYISHMHSDH LSYPTLKQLS QRRPDIPIYV GDTERPVFWN LDQSGVGLTN 240
INVVPFGIWQ QVDKSLRFMI LMDGVHPEMD TCIIVEYKGH KILNTVDCTR PNGGRLPEKV 300
ALMMSDFAGG ASGFPMTFSG GKFTEEWKAQ FIKAERRKLL NYKAQLVKDL QPRIYCPFAG 360
YFVESHPSDK YIKETNTKND PNQLNNLIRK NSDVVTWTPR PGAVLDLGRM LKDPTDSKGI 420
VEPPEGTKIY KDSWDFGPYL EILNSAVRDE IFCHSSWIKE YFTWAGFKNY NLVVRMIETD 480
EDFSPFPGGY DYLVDFLDLS FPKERPSREH PYEEIHSRVD VIRYVVKNGL LWDDLYIGFQ 540
TRLLRDPDIY HHLFWNHFQI KLPLTPPNWK SFLMHCD 577 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:MGI. GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell. GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW. GO:0030338; F:CMP-N-acetylneuraminate monooxygenase activity; IMP:UniProtKB. GO:0016787; F:hydrolase activity; IEA:InterPro. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0046381; P:CMP-N-acetylneuraminate metabolic process; IDA:MGI. GO:0022900; P:electron transport chain; IEA:UniProtKB-KW. GO:0006054; P:N-acetylneuraminate metabolic process; IEA:UniProtKB-UniPathway. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |