| Tag | Content |
|---|
| CPLM ID | CPLM-024384 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Cytochrome P450 4V2 |
Protein Synonyms/Alias | |
Gene Name | Cyp4v2 |
Gene Synonyms/Alias | Cyp4v3 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 376 | PVTLEDLKKLKYLDC | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Catalyzes the omega-hydroxylation of medium-chain saturated fatty acids such as laurate, myristate and palmitate in an NADPH-dependent pathway. The substrate specificity is higher for myristate > laurate > palmitate (C14>C16>C12) (By similarity). |
Sequence Annotation | METAL 467 467 Iron (heme axial ligand) (By similarity).
BINDING 329 329 Heme (covalent; via 1 link) (By
MOD_RES 403 403 Phosphoserine (By similarity). |
Keyword | Complete proteome; Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Monooxygenase; Oxidoreductase; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 525 AA |
Protein Sequence | MLWLWLGLSG QKLLLWGAAS AVSVAGATVL LNILQMLVSY ARKWQQMRPI PSVARAYPLV 60
GHALFMKPNN TEFFQQIIQY TEEFRHLPII KLWIGPVPLV ALYKAENVEV ILTSSKQIDK 120
SFMYKFLQPW LGLGLLTSTG SKWRARRKML TPSFHFTILE DFLDVMNEQA NILVNKLEKH 180
VNQEAFNCFF PITLCALDII CETAMGKNIG AQSNGDSEYV RTVYRMSDMI YRRMKMPWFW 240
FDLWYLMFKE GRDHKKGLKS LHTFTNNVIA ERVNARKAEQ DCIGAGRGPL PSKTKRKAFL 300
DLLLSVTDEE GNKLSHEDIR EEVDTFMFEG HDTTAAAINW SLYLLGSNPE VQRKVDKELD 360
DVFGRSHRPV TLEDLKKLKY LDCVIKETLR VFPSVPLFAR SLSEDCEVAG YKISKGTEAV 420
IIPYALHRDP RYFPDPEEFQ PERFFPENSQ GRHPYAYVPF SAGPRNCIGQ KFAVMEEKTI 480
LACILREFWI ESNQKREELG LAGDLILRPN NGIWIKLKRR HEDDP 525 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0009055; F:electron carrier activity; IEA:InterPro. GO:0020037; F:heme binding; IEA:InterPro. GO:0005506; F:iron ion binding; IEA:InterPro. GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW. GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro. GO:0010430; P:fatty acid omega-oxidation; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |