CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013332
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Charged multivesicular body protein 5 
Protein Synonyms/Alias
 Chromatin-modifying protein 5 
Gene Name
 Chmp5 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
58KMREGPAKNMVKQKAacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405
Functional Description
 Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT- III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4 (By similarity). 
Sequence Annotation
 MOD_RES 219 219 Phosphoserine (By similarity).  
Keyword
 Coiled coil; Complete proteome; Cytoplasm; Endosome; Membrane; Phosphoprotein; Protein transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 219 AA 
Protein Sequence
MNRFFGKAKP KAPPPSLTDC IGTVDSRAES IDKKISRLDA ELVKYKDQIK KMREGPAKNM 60
VKQKALRVLK QKRMYEQQRD NLAQQSFNME QANYTIQSLK DTKTTVDAMK LGVKEMKKAY 120
KEVKIDQIED LQDQLEDMME DANEIQEALG RSYGTPELDE DDLEAELDAL GDELLADEDS 180
SYLDEAASAP AIPEGVPTDT KNKDGVLVDE FGLPQIPAS 219 
Gene Ontology
 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 
Interpro
 IPR005024; Snf7. 
Pfam
 PF03357; Snf7 
SMART
  
PROSITE
  
PRINTS