CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029118
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein transport protein Sec61 subunit alpha isoform 2 
Protein Synonyms/Alias
  
Gene Name
 SEC61A2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
4****MGIKFLEVIKPubiquitination[1]
21AVLPEIQKPERKIQFubiquitination[2]
107IEVGDTPKDRALFNGubiquitination[2, 3, 4]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 168 AA 
Protein Sequence
MGIKFLEVIK PFCAVLPEIQ KPERKIQFRE KVLWTAITLF IFLVCCQIPL FGIMSSDSAD 60
PFYWMRVILA SNRGTLMELG ISPIVTSGLI MQLLAGAKII EVGDTPKDRA LFNGAQKLFG 120
MIITIGQAIV YVMTGMYGDP AEMGAGICLL IIIQALLTLK ICGYTEEL 168 
Gene Ontology
 GO:0016020; C:membrane; IEA:InterPro.
 GO:0015031; P:protein transport; IEA:InterPro. 
Interpro
 IPR002208; SecY/SEC61-alpha.
 IPR023201; SecY_su_dom.
 IPR019561; Translocon_Sec61/SecY_plug_dom. 
Pfam
 PF10559; Plug_translocon
 PF00344; SecY 
SMART
  
PROSITE
 PS00755; SECY_1 
PRINTS