CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043156
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Tyrosine-protein kinase receptor TYRO3 
Protein Synonyms/Alias
  
Gene Name
 TYRO3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
481TLGRMLGKGEFGSVRubiquitination[1]
537FDHPHVAKLVGVSLRubiquitination[2]
707LIGGNRLKQPPECMEubiquitination[3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 845 AA 
Protein Sequence
MGAPVKLTVS QGQPVKLNCS VEGMEEPDIQ WVKDGAVVQN LDQLYIPVSE QHWIGFLSLK 60
SVERSDAGRY WCQVEDGGET EISQPVWLTV EGVPFFTVEP KDLAVPPNAP FQLSCEAVGP 120
PEPVTIVWWR GTTKIGGPAP SPSVLNVTGV TQSTMFSCEA HNLKGLASSR TATVHLQALP 180
AAPFNITVTK LSSSNASVAW MPGADGRALL QSCTVQVTQA PGGWEVLAVV VPVPPFTCLL 240
RDLVPATNYS LRVRCANALG PSPYADWVPF QTKGLAPASA PQNLHAIRTD SGLILEWEEV 300
IPEAPLEGPL GPYKLSWVQD NGTQDELTVE GTRANLTGWD PQKDLIVRVC VSNAVGCGPW 360
SQPLVVSSHD RAGQQGPPHS RTSWVPVVLG VLTALVTAAA LALILLRKRR KETRFGQAFD 420
SVMARGEPAV HFRAARSFNR ERPERIEATL DSLGISDELK EKLEDVLIPE QQFTLGRMLG 480
KGEFGSVREA QLKQEDGSFV KVAVKMLKAD IIASSDIEEF LREAACMKEF DHPHVAKLVG 540
VSLRSRAKGR LPIPMVILPF MKHGDLHAFL LASRIGENPF NLPLQTLIRF MVDIACGMEY 600
LSSRNFIHRD LAARNCMLAE DMTVCVADFG LSRKIYSGDY YRQGCASKLP VKWLALESLA 660
DNLYTVQSDV WAFGVTMWEI MTRGQTPYAG IENAEIYNYL IGGNRLKQPP ECMEDVYDLM 720
YQCWSADPKQ RPSFTCLRME LENILGQLSV LSASQDPLYI NIERAEEPTA GGSLELPGRD 780
QPYSGAGDGS GMGAVGGTPS DCRYILTPGG LAEQPGQAEH QPESPLNETQ RLLLLQQGLL 840
PHSSC 845 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
 GO:0043277; P:apoptotic cell clearance; IEA:Compara.
 GO:0021885; P:forebrain cell migration; IEA:Compara.
 GO:0001779; P:natural killer cell differentiation; IEA:Compara.
 GO:0050728; P:negative regulation of inflammatory response; IEA:Compara.
 GO:0045824; P:negative regulation of innate immune response; IEA:Compara.
 GO:0051250; P:negative regulation of lymphocyte activation; IEA:Compara.
 GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Compara.
 GO:0034122; P:negative regulation of toll-like receptor signaling pathway; IEA:Compara.
 GO:0070050; P:neuron homeostasis; IEA:Compara.
 GO:0042698; P:ovulation cycle; IEA:Compara.
 GO:0070527; P:platelet aggregation; IEA:Compara.
 GO:0043491; P:protein kinase B signaling cascade; IEA:Compara.
 GO:0032940; P:secretion by cell; IEA:Compara.
 GO:0007283; P:spermatogenesis; IEA:Compara.
 GO:0034446; P:substrate adhesion-dependent cell spreading; IEA:Compara.
 GO:0060068; P:vagina development; IEA:Compara. 
Interpro
 IPR003961; Fibronectin_type3.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013098; Ig_I-set.
 IPR003599; Ig_sub.
 IPR003598; Ig_sub2.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
 IPR008266; Tyr_kinase_AS.
 IPR020635; Tyr_kinase_cat_dom. 
Pfam
 PF00041; fn3
 PF07679; I-set
 PF07714; Pkinase_Tyr 
SMART
 SM00060; FN3
 SM00409; IG
 SM00408; IGc2
 SM00219; TyrKc 
PROSITE
 PS50853; FN3
 PS50835; IG_LIKE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00109; PROTEIN_KINASE_TYR 
PRINTS
 PR00109; TYRKINASE.