CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-003810
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transforming growth factor beta-3 
Protein Synonyms/Alias
 TGF-beta-3; Latency-associated peptide; LAP 
Gene Name
 TGFB3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
162RVPNPSSKRNEQRIEmethylation[1]
Reference
 [1] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510
Functional Description
 Involved in embryogenesis and cell differentiation. 
Sequence Annotation
 MOTIF 261 263 Cell attachment site (Potential).
 CARBOHYD 74 74 N-linked (GlcNAc...) (Potential).
 CARBOHYD 135 135 N-linked (GlcNAc...) (Potential).
 CARBOHYD 142 142 N-linked (GlcNAc...) (Potential).
 DISULFID 307 316
 DISULFID 315 378
 DISULFID 344 409
 DISULFID 348 411
 DISULFID 377 377 Interchain (By similarity).  
Keyword
 3D-structure; Cardiomyopathy; Cleavage on pair of basic residues; Complete proteome; Disulfide bond; Glycoprotein; Growth factor; Mitogen; Polymorphism; Reference proteome; Secreted; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 412 AA 
Protein Sequence
MKMHLQRALV VLALLNFATV SLSLSTCTTL DFGHIKKKRV EAIRGQILSK LRLTSPPEPT 60
VMTHVPYQVL ALYNSTRELL EEMHGEREEG CTQENTESEY YAKEIHKFDM IQGLAEHNEL 120
AVCPKGITSK VFRFNVSSVE KNRTNLFRAE FRVLRVPNPS SKRNEQRIEL FQILRPDEHI 180
AKQRYIGGKN LPTRGTAEWL SFDVTDTVRE WLLRRESNLG LEISIHCPCH TFQPNGDILE 240
NIHEVMEIKF KGVDNEDDHG RGDLGRLKKQ KDHHNPHLIL MMIPPHRLDN PGQGGQRKKR 300
ALDTNYCFRN LEENCCVRPL YIDFRQDLGW KWVHEPKGYY ANFCSGPCPY LRSADTTHST 360
VLGLYNTLNP EASASPCCVP QDLEPLTILY YVGRTPKVEQ LSNMVVKSCK CS 412 
Gene Ontology
 GO:0009986; C:cell surface; IEA:Compara.
 GO:0031012; C:extracellular matrix; IDA:BHF-UCL.
 GO:0005576; C:extracellular region; TAS:Reactome.
 GO:0005615; C:extracellular space; IEA:Compara.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0005886; C:plasma membrane; IC:BHF-UCL.
 GO:0031093; C:platelet alpha granule lumen; TAS:Reactome.
 GO:0030315; C:T-tubule; IEA:Compara.
 GO:0042802; F:identical protein binding; IDA:BHF-UCL.
 GO:0050431; F:transforming growth factor beta binding; IDA:BHF-UCL.
 GO:0034713; F:type I transforming growth factor beta receptor binding; IDA:BHF-UCL.
 GO:0005114; F:type II transforming growth factor beta receptor binding; IDA:BHF-UCL.
 GO:0000187; P:activation of MAPK activity; IEA:Compara.
 GO:0007568; P:aging; IEA:Compara.
 GO:0016049; P:cell growth; IEA:InterPro.
 GO:0045216; P:cell-cell junction organization; IDA:BHF-UCL.
 GO:0070483; P:detection of hypoxia; IDA:BHF-UCL.
 GO:0048565; P:digestive tract development; IEA:Compara.
 GO:0048702; P:embryonic neurocranium morphogenesis; IEA:Compara.
 GO:0030198; P:extracellular matrix organization; TAS:Reactome.
 GO:0060325; P:face morphogenesis; IMP:BHF-UCL.
 GO:0007565; P:female pregnancy; IEA:Compara.
 GO:0060364; P:frontal suture morphogenesis; IEA:Compara.
 GO:0001701; P:in utero embryonic development; ISS:BHF-UCL.
 GO:0006917; P:induction of apoptosis; ISS:BHF-UCL.
 GO:0048839; P:inner ear development; IEA:Compara.
 GO:0048286; P:lung alveolus development; ISS:BHF-UCL.
 GO:0030879; P:mammary gland development; ISS:BHF-UCL.
 GO:0022601; P:menstrual cycle phase; IEP:BHF-UCL.
 GO:0008285; P:negative regulation of cell proliferation; ISS:BHF-UCL.
 GO:0008156; P:negative regulation of DNA replication; IMP:BHF-UCL.
 GO:0010936; P:negative regulation of macrophage cytokine production; IDA:DFLAT.
 GO:0043524; P:negative regulation of neuron apoptotic process; ISS:BHF-UCL.
 GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IEA:Compara.
 GO:0042476; P:odontogenesis; NAS:BHF-UCL.
 GO:0043932; P:ossification involved in bone remodeling; IEP:BHF-UCL.
 GO:0060021; P:palate development; ISS:BHF-UCL.
 GO:0030168; P:platelet activation; TAS:Reactome.
 GO:0002576; P:platelet degranulation; TAS:Reactome.
 GO:0030501; P:positive regulation of bone mineralization; IEP:BHF-UCL.
 GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
 GO:0032967; P:positive regulation of collagen biosynthetic process; IMP:BHF-UCL.
 GO:0045740; P:positive regulation of DNA replication; IMP:BHF-UCL.
 GO:0010718; P:positive regulation of epithelial to mesenchymal transition; IDA:BHF-UCL.
 GO:0051491; P:positive regulation of filopodium assembly; ISS:BHF-UCL.
 GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; ISS:BHF-UCL.
 GO:0050714; P:positive regulation of protein secretion; IDA:BHF-UCL.
 GO:0060391; P:positive regulation of SMAD protein import into nucleus; ISS:BHF-UCL.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:BHF-UCL.
 GO:0043627; P:response to estrogen stimulus; IEA:Compara.
 GO:0034616; P:response to laminar fluid shear stress; IEA:Compara.
 GO:0032570; P:response to progesterone stimulus; IDA:BHF-UCL.
 GO:0007435; P:salivary gland morphogenesis; IEP:BHF-UCL.
 GO:0007184; P:SMAD protein import into nucleus; IEA:Compara.
 GO:0007179; P:transforming growth factor beta receptor signaling pathway; IDA:BHF-UCL. 
Interpro
 IPR001839; TGF-b_C.
 IPR001111; TGF-b_N.
 IPR016319; TGF-beta.
 IPR015615; TGF-beta-rel.
 IPR017948; TGFb_CS.
 IPR015618; Transform_grow_fac_b3. 
Pfam
 PF00019; TGF_beta
 PF00688; TGFb_propeptide 
SMART
 SM00204; TGFB 
PROSITE
 PS00250; TGF_BETA_1
 PS51362; TGF_BETA_2 
PRINTS
 PR01423; TGFBETA.
 PR01426; TGFBETA3.