CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025364
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Urocanate hydratase 
Protein Synonyms/Alias
  
Gene Name
 Uroc1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
242GIENLAGKVFVTSGLubiquitination[1]
455AGADVEKKGANKMEFacetylation[2]
459VEKKGANKMEFRYPSubiquitination[1]
515KAIADGVKASVKLQYubiquitination[1]
519DGVKASVKLQYMDNIacetylation[3, 4]
519DGVKASVKLQYMDNIubiquitination[1]
534RWIREAAKHQLVVGSacetylation[3]
534RWIREAAKHQLVVGSubiquitination[1]
551RILYSDQKGRVAIAVubiquitination[1]
568NQAIASGKIKAPVVLacetylation[5]
568NQAIASGKIKAPVVLsuccinylation[5]
568NQAIASGKIKAPVVLubiquitination[1]
570AIASGKIKAPVVLSRubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [3] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [4] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [5] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 710 AA 
Protein Sequence
MSSLQELCSG LPLRPLPENR GRWAGVPHAP VRTPNLSPEE EQLALRNALR YFPPDVQKLL 60
ALEFAQELRQ FGHIYMYRFC PSIEMRAYPI DQYPCRTRAA AAIMHMIMNN LDPAVAQFPQ 120
ELVTYGGNGQ VFSNWAQFRL TMSYLSKMTE EQTLVMYSGH PLGLFPSSPR APRLVITNGM 180
VIPNYSSRTE YEKLFALGVT MYGQMTAGSY CYIGPQGIVH GTVLTVLNAG RRYLGIENLA 240
GKVFVTSGLG GMSGAQAKAA AIVGCIGVIA EVDKAALVKR HRQGWLMEVT DSLDRCIARL 300
RYGLAVWDPE HLTLSTGSRG ESMTWAIQCL MFDHREARKK KEVLSLGYHG NVVDLWERLV 360
HELDTTGELL VDLGSDQTSC HNPFNGGYYP VQLSFSEAQS LMSSNPAAFK HLVQESLRRH 420
VAAINRLAQE KFFFWDYGNA FLLEAQRAGA DVEKKGANKM EFRYPSYVQH IMGDIFSQGF 480
GPFRWVCTSG DPQDLAVTDH LATSVLEKAI ADGVKASVKL QYMDNIRWIR EAAKHQLVVG 540
SQARILYSDQ KGRVAIAVAI NQAIASGKIK APVVLSRDHH DVSGTDSPFR ETSNIYDGSA 600
FCADMAVQNF VGDACRGATW VALHNGGGVG WGEVINGGFG LVLDGTAEAE QKARMMLSWD 660
VSNGVARRCW SGNPKAYEII CQTMQENSGL VVTLPHEVAD EQVLQQALRP 710 
Gene Ontology
 GO:0016153; F:urocanate hydratase activity; IEA:InterPro. 
Interpro
 IPR023637; Urocanase.
 IPR023636; Urocanase_CS. 
Pfam
 PF01175; Urocanase 
SMART
  
PROSITE
 PS01233; UROCANASE 
PRINTS