UniProt Accession

 ISCU_HUMAN; Q9H1K1; Q6P713; Q99617; Q9H1K2 

Genbank Protein ID

 AY009127; AY009128; AC008119; BC011906; BC061903; U47101 

Genbank Nucleotide ID

 AAG37427.1; AAG37428.1; AAH11906.1; AAH61903.1; AAC50885.1 

Protein Name

 Iron-sulfur cluster assembly enzyme ISCU, mitochondrial 

Protein Synonyms/Alias

 NifU-like N-terminal domain-containing protein; NifU-like protein 

Gene Name

 ISCU 

Gene Synonyms/Alias

 NIFUN 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
54	RNVGSLDKTSKNVGT	ubiquitination	[1, 2]
57	GSLDKTSKNVGTGLV	ubiquitination	[1, 2]
82	LQIQVDEKGKIVDAR	ubiquitination	[1, 2]
91	KIVDARFKTFGCGSA	ubiquitination	[1, 2]
112	ATEWVKGKTVEEALT	ubiquitination	[1, 2]
121	VEEALTIKNTDIAKE	ubiquitination	[1, 2]
147	MLAEDAIKAALADYK	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Involved in the assembly or repair of the [Fe-S] clusters present in iron-sulfur proteins. Binds iron. 

Sequence Annotation

  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; Iron; Metal-binding; Mitochondrion; Nucleus; Polymorphism; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 167 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:HGNC.
 GO:0005759; C:mitochondrial matrix; TAS:Reactome.
 GO:0005634; C:nucleus; TAS:HGNC.
 GO:0005506; F:iron ion binding; TAS:UniProtKB.
 GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
 GO:0032947; F:protein complex scaffold; IDA:HGNC.
 GO:0016226; P:iron-sulfur cluster assembly; TAS:UniProtKB.
 GO:0009399; P:nitrogen fixation; TAS:UniProtKB.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 

Interpro

 IPR011339; ISC_FeS_clus_asmbl_IscU.
 IPR002871; NIF_FeS_clus_asmbl_NifU_N. 

Pfam

 PF01592; NifU_N 

SMART

  

PROSITE

  

PRINTS