CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017962
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Phosphatidylinositol-glycan biosynthesis class X protein 
Protein Synonyms/Alias
 PIG-X 
Gene Name
 PIGX 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
82HTCRLLIKQDIPAGLubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Essential component of glycosylphosphatidylinositol- mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase PIGM (By similarity). 
Sequence Annotation
 CARBOHYD 103 103 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Complete proteome; Endoplasmic reticulum; Glycoprotein; GPI-anchor biosynthesis; Membrane; Polymorphism; Reference proteome; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 258 AA 
Protein Sequence
MAARVAAVRA AAWLLLGAAT GLTRGPAAAF TAARSDAGIR AMCSEIILRQ EVLKDGFHRD 60
LLIKVKFGES IEDLHTCRLL IKQDIPAGLY VDPYELASLR ERNITEAVMV SENFDIEAPN 120
YLSKESEVLI YARRDSQCID CFQAFLPVHC RYHRPHSEDG EASIVVNNPD LLMFCDQEFP 180
ILKCWAHSEV AAPCALENED ICQWNKMKYK SVYKNVILQV PVGLTVHTSL VCSVTLLITI 240
LCSTLILVAV FKYGHFSL 258 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0006501; P:C-terminal protein lipidation; TAS:Reactome.
 GO:0016254; P:preassembly of GPI anchor in ER membrane; TAS:Reactome. 
Interpro
 IPR013233; PIG-X/PBN1. 
Pfam
 PF08320; PIG-X 
SMART
 SM00780; PIG-X 
PROSITE
  
PRINTS