CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013126
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Calcium uniporter protein, mitochondrial 
Protein Synonyms/Alias
 Coiled-coil domain-containing protein 109A 
Gene Name
 Mcu 
Gene Synonyms/Alias
 Ccdc109a 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
210VERLEDLKQQLAPLEacetylation[1]
218QQLAPLEKVRIEISRacetylation[1]
331AQAEMDLKRLRDPLQacetylation[1, 2, 3, 4, 5]
Reference
 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [5] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 
Functional Description
 Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondrion. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes. 
Sequence Annotation
  
Keyword
 Alternative splicing; Calcium; Calcium channel; Calcium transport; Coiled coil; Complete proteome; Ion channel; Ion transport; Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 350 AA 
Protein Sequence
MAAAAGRSLL LLLCSRGGGG GAGGCGALTA GCFPGLGVSR HRPHQQHRTA HQRPASWQSV 60
GAAYCSTVVP SDDVTVVYQN GLPVISVRLP SRRERCQFTL KPISDSVGVF LRQLQEEDRG 120
IDRVAIYSPD GVRVAASTGI DLLLLDDFKL VINDLTYHVR PPKRDLLSHE DAATLNDVKT 180
LVQQLYTTLC IEQHQLNKER ELVERLEDLK QQLAPLEKVR IEISRKAEKR TTLVLWGGLA 240
YMATQFGILA RLTWWEYSWD IMEPVTYFIT YGSAMAMYAY FVMTRQEYVY PEARDRQYLL 300
FFHKGAKKSR FDLEKYNQLK DAIAQAEMDL KRLRDPLQVH LPLRQIGEKE 350 
Gene Ontology
 GO:0034704; C:calcium channel complex; IDA:UniProtKB.
 GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
 GO:0005262; F:calcium channel activity; ISS:UniProtKB.
 GO:0015292; F:uniporter activity; IEA:Compara.
 GO:0019722; P:calcium-mediated signaling; ISS:UniProtKB.
 GO:0051561; P:elevation of mitochondrial calcium ion concentration; IMP:UniProtKB.
 GO:0042593; P:glucose homeostasis; ISS:UniProtKB.
 GO:0006851; P:mitochondrial calcium ion transport; IMP:UniProtKB.
 GO:0032024; P:positive regulation of insulin secretion; ISS:UniProtKB.
 GO:0035786; P:protein complex oligomerization; ISS:UniProtKB. 
Interpro
 IPR006769; Coiled-coil-dom_prot_109_C. 
Pfam
 PF04678; DUF607 
SMART
  
PROSITE
  
PRINTS