CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022869
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sodium/hydrogen exchanger 2 
Protein Synonyms/Alias
 Na(+)/H(+) exchanger 2; NHE-2; Solute carrier family 9 member 2 
Gene Name
 SLC9A2 
Gene Synonyms/Alias
 NHE2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
536KFKKFDDKYLRKLLIubiquitination[1, 2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Seems to play an important role in colonic sodium absorption. 
Sequence Annotation
 CARBOHYD 350 350 N-linked (GlcNAc...) (Potential).  
Keyword
 Antiport; Complete proteome; Glycoprotein; Ion transport; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Sodium; Sodium transport; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 812 AA 
Protein Sequence
MEPLGNWRSL RAPLPPMLLL LLLQVAGPVG ALAETLLNAP RAMGTSSSPP SPASVVAPGT 60
TLFEESRLPV FTLDYPHVQI PFEITLWILL ASLAKIGFHL YHKLPTIVPE SCLLIMVGLL 120
LGGIIFGVDE KSPPAMKTDV FFLYLLPPIV LDAGYFMPTR PFFENIGTIF WYAVVGTLWN 180
SIGIGVSLFG ICQIEAFGLS DITLLQNLLF GSLISAVDPV AVLAVFENIH VNEQLYILVF 240
GESLLNDAVT VVLYNLFKSF CQMKTIETID VFAGIANFFV VGIGGVLIGI FLGFIAAFTT 300
RFTHNIRVIE PLFVFLYSYL SYITAEMFHL SGIMAITACA MTMNKYVEEN VSQKSYTTIK 360
YFMKMLSSVS ETLIFIFMGV STVGKNHEWN WAFVCFTLAF CLMWRALGVF VLTQVINRFR 420
TIPLTFKDQF IIAYGGLRGA ICFALVFLLP AAVFPRKKLF ITAAIVVIFF TVFILGITIR 480
PLVEFLDVKR SNKKQQAVSE EIYCRLFDHV KTGIEDVCGH WGHNFWRDKF KKFDDKYLRK 540
LLIRENQPKS SIVSLYKKLE IKHAIEMAET GMISTVPTFA SLNDCREEKI RKVTSSETDE 600
IRELLSRNLY QIRQRTLSYN RHSLTADTSE RQAKEILIRR RHSLRESIRK DSSLNREHRA 660
STSTSRYLSL PKNTKLPEKL QKRRTISIAD GNSSDSDADA GTTVLNLQPR ARRFLPEQFS 720
KKSPQSYKME WKNEVDVDSG RDMPSTPPTP HSREKGTQTS GLLQQPLLSK DQSGSEREDS 780
LTEGIPPKPP PRLVWRASEP GSRKARFGSE KP 812 
Gene Ontology
 GO:0016021; C:integral to membrane; TAS:ProtInc.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0015385; F:sodium:hydrogen antiporter activity; TAS:ProtInc.
 GO:0008104; P:protein localization; IEA:Compara.
 GO:0006885; P:regulation of pH; IEA:Compara. 
Interpro
 IPR006153; Cation/H_exchanger.
 IPR018422; Cation/H_exchanger_CPA1.
 IPR001953; Na/H_exchanger_2.
 IPR004709; NaH_exchanger. 
Pfam
 PF00999; Na_H_Exchanger 
SMART
  
PROSITE
  
PRINTS
 PR01084; NAHEXCHNGR.
 PR01086; NAHEXCHNGR2.