CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000697
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Heterogeneous nuclear ribonucleoprotein R 
Protein Synonyms/Alias
 hnRNP R 
Gene Name
 HNRNPR 
Gene Synonyms/Alias
 HNRPR 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
171GTEVFVGKIPRDLYEubiquitination[1]
187ELVPLFEKAGPIWDLubiquitination[1]
362VTEEILEKSFSEFGKubiquitination[1]
369KSFSEFGKLERVKKLubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Component of ribonucleosomes, which are complexes of at least 20 other different heterogenious nuclear ribonucleoproteins (hnRNP). hnRNP play an important role in processing of precursor mRNA in the nucleus. 
Sequence Annotation
 DOMAIN 165 244 RRM 1.
 DOMAIN 246 328 RRM 2.
 DOMAIN 341 411 RRM 3.
 REPEAT 462 471 1; approximate.
 REPEAT 472 482 2.
 REPEAT 488 497 3; approximate.
 REGION 447 567 RNA-binding RGG-box.
 REGION 462 497 3 X 11 AA approximate repeats of D-D-Y-Y-
 MOTIF 412 418 Nuclear localization signal (Potential).
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 366 366 N6-acetyllysine.  
Keyword
 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat; Ribonucleoprotein; RNA-binding; Spliceosome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 633 AA 
Protein Sequence
MANQVNGNAV QLKEEEEPMD TSSVTHTEHY KTLIEAGLPQ KVAERLDEIF QTGLVAYVDL 60
DERAIDALRE FNEEGALSVL QQFKESDLSH VQNKSAFLCG VMKTYRQREK QGSKVQESTK 120
GPDEAKIKAL LERTGYTLDV TTGQRKYGGP PPDSVYSGVQ PGIGTEVFVG KIPRDLYEDE 180
LVPLFEKAGP IWDLRLMMDP LSGQNRGYAF ITFCGKEAAQ EAVKLCDSYE IRPGKHLGVC 240
ISVANNRLFV GSIPKNKTKE NILEEFSKVT GLTEGLVDVI LYHQPDDKKK NRGFCFLEYE 300
DHKSAAQARR RLMSGKVKVW GNVVTVEWAD PVEEPDPEVM AKVKVLFVRN LATTVTEEIL 360
EKSFSEFGKL ERVKKLKDYA FVHFEDRGAA VKAMDEMNGK EIEGEEIEIV LAKPPDKKRK 420
ERQAARQASR STAYEDYYYH PPPRMPPPIR GRGRGGGRGG YGYPPDYYGY EDYYDDYYGY 480
DYHDYRGGYE DPYYGYDDGY AVRGRGGGRG GRGAPPPPRG RGAPPPRGRA GYSQRGAPLG 540
PPRGSRGGRG GPAQQQRGRG SRGSRGNRGG NVGGKRKADG YNQPDSKRRQ TNNQQNWGSQ 600
PIAQQPLQQG GDYSGNYGYN NDNQEFYQDT YGQQWK 636 
Gene Ontology
 GO:0071013; C:catalytic step 2 spliceosome; IDA:UniProtKB.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005654; C:nucleoplasm; IDA:UniProtKB.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; NAS:UniProtKB.
 GO:0000398; P:mRNA splicing, via spliceosome; IC:UniProtKB. 
Interpro
 IPR006535; HnRNP_R/Q_splicing_fac.
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 
Pfam
 PF00076; RRM_1 
SMART
 SM00360; RRM 
PROSITE
 PS50102; RRM 
PRINTS