| Tag | Content |
|---|
| CPLM ID | CPLM-021678 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Platelet glycoprotein VI |
Protein Synonyms/Alias | GPVI; Glycoprotein 6 |
Gene Name | GP6 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 380 | GQRLQLWKRGHAASS | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma- chain, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2. |
Sequence Annotation | DOMAIN 26 104 Ig-like C2-type 1.
DOMAIN 114 196 Ig-like C2-type 2.
CARBOHYD 92 92 N-linked (GlcNAc...).
DISULFID 48 88
DISULFID 134 180 |
Keyword | 3D-structure; Alternative splicing; Blood coagulation; Cell membrane; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; Glycoprotein; Hemostasis; Immunoglobulin domain; Membrane; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 339 AA |
Protein Sequence | MSPSPTALFC LGLCLGRVPA QSGPLPKPSL QALPSSLVPL EKPVTLRCQG PPGVDLYRLE 60
KLSSSRYQDQ AVLFIPAMKR SLAGRYRCSY QNGSLWSLPS DQLELVATGV FAKPSLSAQP 120
GPAVSSGGDV TLQCQTRYGF DQFALYKEGD PAPYKNPERW YRASFPIITV TAAHSGTYRC 180
YSFSSRDPYL WSAPSDPLEL VVTGTSVTPS RLPTEPPSPV AEFSEATAEL TVSFTNEVFT 240
TETSRSITAS PKESDSPAGE SCPPVLHQGQ PGPDMPRGCD PNNPGGVSGR GLAQPEEAPA 300
AQGQGCAEAA SAPPAPPADP EIKRGSGWRP TGCSQPRVMF MTAEPQARSY PREGSWHGRR 360
LKDWRVWSVE AGGQRLQLWK RGHAASSWCS IREPFGQCLS VCLPLCLRAP SIWDGRNLWR 420
PHPPPCTLWM TWYPGWTTYW PLSSTSLIWA PDGSLRFPAL RVDSVPSSVQ NPPVLPFGPL 480
CSCLVFPRNS HPHSISHCGL TNLLSSLRTG LAGSLGMSFI FLSVKLARCP LPFTLENKIS 540
LCNMVKPHLY QQNKKTQKLA RCGGASLYSQ QLRGLRWENG LSLGGRGCSE LRSHHCTLAR 600
VTKPDFVSKN TGMNMSITLI 620 |
Gene Ontology | GO:0005887; C:integral to plasma membrane; TAS:ProtInc. GO:0005518; F:collagen binding; TAS:UniProtKB. GO:0004888; F:transmembrane signaling receptor activity; TAS:ProtInc. GO:0007167; P:enzyme linked receptor protein signaling pathway; TAS:ProtInc. GO:0050900; P:leukocyte migration; TAS:Reactome. GO:0030168; P:platelet activation; NAS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |