| Tag | Content |
|---|
| CPLM ID | CPLM-017918 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Exocyst complex component 6 |
Protein Synonyms/Alias | Exocyst complex component Sec15A; SEC15-like protein 1 |
Gene Name | EXOC6 |
Gene Synonyms/Alias | SEC15A; SEC15L; SEC15L1 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 478 | EKQSFPKKFPMSQSV | ubiquitination | [1] |
|
Reference | [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C. Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [ PMID: 21890473] |
Functional Description | Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Together with RAB11A, RAB3IP, RAB8A, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (By similarity). |
Sequence Annotation | |
Keyword | Alternative splicing; Complete proteome; Exocytosis; Polymorphism; Protein transport; Reference proteome; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 804 AA |
Protein Sequence | MAENSESLGT VPEHERILQE IESTDTACVG PTLRSVYDDQ PNAHKKFMEK LDACIRNHDK 60
EIEKMCNFHH QGFVDAITEL LKVRTDAEKL KVQVTDTNRR FQDAGKEVIV HTEDIIRCRI 120
QQRNITTVVE KLQLCLPVLE MYSKLKEQMS AKRYYSALKT MEQLENVYFP WVSQYRFCQL 180
MIENLPKLRE DIKEISMSDL KDFLESIRKH SDKIGETAMK QAQHQKTFSV SLQKQNKMKF 240
GKNMYINRDR IPEERNETVL KHSLEEEDEN EEEILTVQDL VDFSPVYRCL HIYSVLGDEE 300
TFENYYRKQR KKQARLVLQP QSNMHETVDG YRRYFTQIVG FFVVEDHILH VTQGLVTRAY 360
TDELWNMALS KIIAVLRAHS SYCTDPDLVL ELKNLTVIFA DTLQGYGFPV NRLFDLLFEI 420
RDQYNETLLK KWAGVFRDIF EEDNYSPIPV VNEEEYKIVI SKFPFQDPDL EKQSFPKKFP 480
MSQSVPHIYI QVKEFIYASL KFSESLHRSS TEIDDMLRKS TNLLLTRTLS SCLLNLIRKP 540
HIGLTELVQI IINTTHLEQA CKYLEDFITN ITNISQETVH TTRLYGLSTF KDARHAAEGE 600
IYTKLNQKID EFVQLADYDW TMSEPDGRAS GYLMDLINFL RSIFQVFTHL PGKVAQTACM 660
SACQHLSTSL MQMLLDSELK QISMGAVQQF NLDVIQCELF ASSEPVPGFQ GDTLQLAFID 720
LRQLLDLFMV WDWSTYLADY GQPASKYLRV NPNTALTLLE KMKDTSKKNN IFAQFRKNDR 780
DKQKLIETVV KQLRSLVNGM SQHM 804 |
Gene Ontology | GO:0000145; C:exocyst; IEA:InterPro. GO:0005886; C:plasma membrane; TAS:Reactome. GO:0016044; P:cellular membrane organization; TAS:Reactome. GO:0044267; P:cellular protein metabolic process; TAS:Reactome. GO:0030218; P:erythrocyte differentiation; IEA:Compara. GO:0015031; P:protein transport; IEA:UniProtKB-KW. GO:0006904; P:vesicle docking involved in exocytosis; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |