CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024963
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 DNA topoisomerase 2 
Protein Synonyms/Alias
  
Gene Name
 Top2b 
Gene Synonyms/Alias
 LOC361100; TOP2B 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
1482PSQTVAAKKGKAPSDacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks (By similarity). 
Sequence Annotation
  
Keyword
 ATP-binding; DNA-binding; Isomerase; Nucleotide-binding; Topoisomerase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1614 AA 
Protein Sequence
MAKSSLAGVD GALTWVNNAA KKEELETANK NDSSKKLSVE RVYQKKTQLE HILLRPDTYI 60
GSVEPLTQLM WVYDEDVGMN CREVTFVPGL YKIFDEILVN AADNKQRDKN MTCIKVSIDP 120
ESNIISIWNN GKGIPVVEHK VEKVYVPALI FGQLLTSSNY DDDEKKVTGG RNGYGAKLCN 180
IFSTKFTVET ACKEYKHSFK QTWMNNMMKT SEAKIKHFDG EDYTCITFQP DLAKFKMEKL 240
DKDIVALMTR RAYDLAGSCK GVKVMFNGKK LPVNGFRSYV DLYVKDKLDE TGVALKVIHE 300
LANERWDVCL TLSEKGFQQI SFVNSIATTK GGRHVDYVVD QVVGKLIEVV KKKNKAGVSV 360
KPFQVKNHIW VFINCLIENP TFDSQTKENM TLQPKSFGSK CQLSEKFFKA ASNCGIVESI 420
LNWVKFKAQT QLNKKCSSVK YSKIKGIPKL DDANDAGGKH SLECTLILTE GDSAKSLAVS 480
GLGVIGRDRY GVFPLRGKIL NAREASHKQI MENAEINNII KIVGLQYKKS YDDAESLKTL 540
RYGKIMIMTD QDQDGSHIKG LLINFIHHNW PSLLKHGFLE EFITPIVKAS KNKQELSFYS 600
IPEFDEWEKH IENQKAWKIK YYKGLGTSTA KEAKEYFADM ERHRILFRYA GPEDDAAITL 660
AFSKKKIDDR KEWLTNFMED RRQRRLHGLP EQFLYGTATK HLTYNDFINK ELILFSNSDN 720
ERSIPSLVDG FKPGQRKVLF TCFKRNDKRE VKVAQLAGSV AEMSAYHHGE QALMMTIVNL 780
AQNFVGSNNI NLLQPIGQFG TRLHGGKDAA SPRYIFTMLS SLARLLFPAV DDNLLKFLYD 840
DNQRVEPEWY IPIIPMVLIN GAEGIGTGWA CKLPNYDARE IVNNVRRMLE GLDPHPMLPN 900
YKNFKGTIQE LGQNQYAVSG EIFVVDRNTV EITELPVRTW TQVYKEQVLE PMLNGTDKTP 960
ALISDYKEYH TDTTVKFVVK MTEEKLAQAE AAGLHKVFKL QTTLTCNSMV LFDHMGCLKK 1020
YETVQDILKE FFDLRLSYYG LRKEWLVGML GAESTKLNNQ ARFILEKIQG KITIENRSKK 1080
DLIQMLVQRG YESDPVKAWK EAQEKAAEEE DAQNPHDDSS SDSGTPSGPD FNYILNMSLW 1140
SLTKEKVEEL IKQRDTKGRE VNDLKRKSPS DLWKEDLAAF VEELDKVEAQ EREDILAGMS 1200
GKAVKGKVGK AKVKKLQLEE TMPSPYGRRI VPEITAMKAD ASRKLLKKKK GDPDTTVVKV 1260
EFDEEFSGTP AEGTGEETLT PSAPVNKGPK PKREKKEPGT RVRKTPASTG KPNTKKVKKR 1320
NPWSDDESKS ESDLEEAEPV VIPRDSLLRR AAAERPKYTF DFSEEEEDDA DDDDDNNDLE 1380
ELKVKASPIT NDGEDEFVPS DGIDKDEYAF SPGKSKATPE KSSHDKKSQD FGNLFSFPSY 1440
SQKSEDDSAK FDSNEEDTTS VFAPSFGLKQ TDKVPSQTVA AKKGKAPSDA AAPKAKRAPR 1500
QRKVVEPANS DSDSELGNIP KKTAAPKGKG RGAKKRKASG SENEGDYNPG RKPSKTASKK 1560
PKKTSFDQDS DVDIFPSDFT SEPPALPRTG RARKEVKYFA ESDEEEDVDF AMFN 1614 
Gene Ontology
 GO:0000795; C:synaptonemal complex; IBA:RefGenome.
 GO:0071778; C:WINAC complex; IBA:RefGenome.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003682; F:chromatin binding; IBA:RefGenome.
 GO:0003918; F:DNA topoisomerase type II (ATP-hydrolyzing) activity; IBA:RefGenome.
 GO:0042826; F:histone deacetylase binding; IBA:RefGenome.
 GO:0005080; F:protein kinase C binding; IBA:RefGenome.
 GO:0006265; P:DNA topological change; IBA:RefGenome.
 GO:0006261; P:DNA-dependent DNA replication; IBA:RefGenome.
 GO:0006312; P:mitotic recombination; IBA:RefGenome.
 GO:0000712; P:resolution of meiotic recombination intermediates; IBA:RefGenome.
 GO:0000819; P:sister chromatid segregation; IBA:RefGenome. 
Interpro
 IPR024946; Arg_repress_C-like.
 IPR012542; DTHCT.
 IPR003594; HATPase_ATP-bd.
 IPR020568; Ribosomal_S5_D2-typ_fold.
 IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
 IPR001241; Topo_IIA.
 IPR002205; Topo_IIA_A/C.
 IPR013758; Topo_IIA_A/C_ab.
 IPR013757; Topo_IIA_A_a.
 IPR013506; Topo_IIA_bsu_dom2.
 IPR013759; Topo_IIA_cen_dom.
 IPR013760; Topo_IIA_like_dom.
 IPR018522; TopoIIA_CS.
 IPR006171; Toprim_domain. 
Pfam
 PF00204; DNA_gyraseB
 PF00521; DNA_topoisoIV
 PF08070; DTHCT
 PF02518; HATPase_c
 PF01751; Toprim 
SMART
 SM00387; HATPase_c
 SM00433; TOP2c
 SM00434; TOP4c 
PROSITE
 PS00177; TOPOISOMERASE_II 
PRINTS
 PR00418; TPI2FAMILY.