UniProt Accession

 GCSH_HUMAN; P23434; Q9H1E9 

Genbank Protein ID

 D00723; M69175; AY310735; AC092718; BC000790; BC020922 

Genbank Nucleotide ID

 BAA00625.1; AAA36011.1; AAP50260.1; AAH00790.1; AAH20922.1 

Protein Name

 Glycine cleavage system H protein, mitochondrial 

Protein Synonyms/Alias

  

Gene Name

 GCSH 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
166	MSEEAYEKYIKSIEE	acetylation	[1, 2]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. 

Sequence Annotation

 MOD_RES 107 107 N6-lipoyllysine.  

Keyword

 Complete proteome; Lipoyl; Mitochondrion; Polymorphism; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 173 AA 

Protein Sequence

Gene Ontology

 GO:0005960; C:glycine cleavage complex; TAS:ProtInc.
 GO:0005739; C:mitochondrion; TAS:ProtInc.
 GO:0004047; F:aminomethyltransferase activity; TAS:ProtInc.
 GO:0006546; P:glycine catabolic process; TAS:ProtInc.
 GO:0019464; P:glycine decarboxylation via glycine cleavage system; IEA:Compara. 

Interpro

 IPR003016; 2-oxoA_DH_lipoyl-BS.
 IPR002930; GCV_H.
 IPR017453; GCV_H_sub.
 IPR011053; Single_hybrid_motif. 

Pfam

 PF01597; GCV_H 

SMART

  

PROSITE

 PS00189; LIPOYL 

PRINTS