UniProt Accession

 RPAC2_HUMAN; Q9Y2S0; Q5TBX2; Q96BR3 

Genbank Protein ID

 AF077044; AK311833; AL136439; AL136439; CH471075; BC000889; BC015319; BC018528 

Genbank Nucleotide ID

 AAD27777.1; BAG34775.1; CAI16933.1; CAI16934.1; EAX08416.1; AAH00889.1; AAH15319.1; AAH18528.1 

Protein Name

 DNA-directed RNA polymerases I and III subunit RPAC2 

Protein Synonyms/Alias

 RNA polymerases I and III subunit AC2; AC19; DNA-directed RNA polymerase I subunit D; RNA polymerase I 16 kDa subunit; RPA16; RPC16; hRPA19 

Gene Name

 POLR1D 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
15	ERKISGLKTSMAEGE	ubiquitination	[1, 2, 3, 4]
24	SMAEGERKTALEMVQ	ubiquitination	[3, 4]
79	TTHPSESKINLRIQT	ubiquitination	[3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. 

Sequence Annotation

 MOD_RES 1 1 N-acetylmethionine.  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Disease mutation; DNA-directed RNA polymerase; Nucleus; Phosphoprotein; Reference proteome; Transcription. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 133 AA 

Protein Sequence

Gene Ontology

 GO:0005736; C:DNA-directed RNA polymerase I complex; IEA:Compara.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0003899; F:DNA-directed RNA polymerase activity; IEA:UniProtKB-KW.
 GO:0006363; P:termination of RNA polymerase I transcription; TAS:Reactome.
 GO:0006386; P:termination of RNA polymerase III transcription; TAS:Reactome.
 GO:0006362; P:transcription elongation from RNA polymerase I promoter; TAS:Reactome.
 GO:0006385; P:transcription elongation from RNA polymerase III promoter; TAS:Reactome.
 GO:0006361; P:transcription initiation from RNA polymerase I promoter; TAS:Reactome. 

Interpro

 IPR009025; DNA-dir_RNA_pol_RBP11-like.
 IPR008193; RNA_pol_Rpb11_13-16kDa_CS. 

Pfam

  

SMART

  

PROSITE

 PS01154; RNA_POL_L_13KD 

PRINTS