CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002580
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Thrombospondin-1 
Protein Synonyms/Alias
  
Gene Name
 THBS1 
Gene Synonyms/Alias
 TSP; TSP1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
1130VVMYEGKKIMADSGPacetylation[1]
Reference
 [1] Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome.
 Morselli E, Mariño G, Bennetzen MV, Eisenberg T, Megalou E, Schroeder S, Cabrera S, Bénit P, Rustin P, Criollo A, Kepp O, Galluzzi L, Shen S, Malik SA, Maiuri MC, Horio Y, López-Otín C, Andersen JS, Tavernarakis N, Madeo F, Kroemer G.
 J Cell Biol. 2011 Feb 21;192(4):615-29. [PMID: 21339330] 
Functional Description
 Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties. 
Sequence Annotation
 DOMAIN 65 270 Laminin G-like.
 DOMAIN 316 373 VWFC.
 DOMAIN 379 429 TSP type-1 1.
 DOMAIN 435 490 TSP type-1 2.
 DOMAIN 492 547 TSP type-1 3.
 DOMAIN 547 587 EGF-like 1.
 DOMAIN 646 690 EGF-like 2.
 REPEAT 691 726 TSP type-3 1.
 REPEAT 727 762 TSP type-3 2.
 REPEAT 763 785 TSP type-3 3.
 REPEAT 786 821 TSP type-3 4.
 REPEAT 822 844 TSP type-3 5.
 REPEAT 845 882 TSP type-3 6.
 REPEAT 883 918 TSP type-3 7.
 REPEAT 919 954 TSP type-3 8.
 DOMAIN 958 1170 TSP C-terminal.
 REGION 47 95 Heparin-binding.
 MOTIF 926 928 Cell attachment site (Probable).
 CARBOHYD 248 248 N-linked (GlcNAc...) (Probable).
 CARBOHYD 360 360 N-linked (GlcNAc...) (Potential).
 CARBOHYD 385 385 C-linked (Man).
 CARBOHYD 394 394 O-linked (Fuc...).
 CARBOHYD 438 438 C-linked (Man).
 CARBOHYD 441 441 C-linked (Man).
 CARBOHYD 450 450 O-linked (Fuc...).
 CARBOHYD 498 498 C-linked (Man).
 CARBOHYD 507 507 O-linked (Fuc...).
 CARBOHYD 708 708 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1067 1067 N-linked (GlcNAc...).
 DISULFID 171 232
 DISULFID 270 270 Interchain (Probable).
 DISULFID 274 274 Interchain (Probable).
 DISULFID 391 423
 DISULFID 395 428
 DISULFID 406 413
 DISULFID 447 484
 DISULFID 451 489
 DISULFID 462 474
 DISULFID 504 541
 DISULFID 508 546
 DISULFID 519 531
 DISULFID 551 562 By similarity.
 DISULFID 556 572 By similarity.
 DISULFID 575 586 By similarity.
 DISULFID 592 608 By similarity.
 DISULFID 599 617 By similarity.
 DISULFID 620 644 By similarity.
 DISULFID 650 663 By similarity.
 DISULFID 657 676 By similarity.
 DISULFID 678 689 By similarity.
 DISULFID 705 713 By similarity.
 DISULFID 718 738 By similarity.
 DISULFID 754 774 By similarity.
 DISULFID 777 797 By similarity.
 DISULFID 813 833 By similarity.
 DISULFID 836 856
 DISULFID 874 894
 DISULFID 910 930
 DISULFID 946 1167  
Keyword
 3D-structure; Calcium; Cell adhesion; Complete proteome; Disulfide bond; EGF-like domain; Glycoprotein; Heparin-binding; Polymorphism; Reference proteome; Repeat; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1170 AA 
Protein Sequence
MGLAWGLGVL FLMHVCGTNR IPESGGDNSV FDIFELTGAA RKGSGRRLVK GPDPSSPAFR 60
IEDANLIPPV PDDKFQDLVD AVRAEKGFLL LASLRQMKKT RGTLLALERK DHSGQVFSVV 120
SNGKAGTLDL SLTVQGKQHV VSVEEALLAT GQWKSITLFV QEDRAQLYID CEKMENAELD 180
VPIQSVFTRD LASIARLRIA KGGVNDNFQG VLQNVRFVFG TTPEDILRNK GCSSSTSVLL 240
TLDNNVVNGS SPAIRTNYIG HKTKDLQAIC GISCDELSSM VLELRGLRTI VTTLQDSIRK 300
VTEENKELAN ELRRPPLCYH NGVQYRNNEE WTVDSCTECH CQNSVTICKK VSCPIMPCSN 360
ATVPDGECCP RCWPSDSADD GWSPWSEWTS CSTSCGNGIQ QRGRSCDSLN NRCEGSSVQT 420
RTCHIQECDK RFKQDGGWSH WSPWSSCSVT CGDGVITRIR LCNSPSPQMN GKPCEGEARE 480
TKACKKDACP INGGWGPWSP WDICSVTCGG GVQKRSRLCN NPTPQFGGKD CVGDVTENQI 540
CNKQDCPIDG CLSNPCFAGV KCTSYPDGSW KCGACPPGYS GNGIQCTDVD ECKEVPDACF 600
NHNGEHRCEN TDPGYNCLPC PPRFTGSQPF GQGVEHATAN KQVCKPRNPC TDGTHDCNKN 660
AKCNYLGHYS DPMYRCECKP GYAGNGIICG EDTDLDGWPN ENLVCVANAT YHCKKDNCPN 720
LPNSGQEDYD KDGIGDACDD DDDNDKIPDD RDNCPFHYNP AQYDYDRDDV GDRCDNCPYN 780
HNPDQADTDN NGEGDACAAD IDGDGILNER DNCQYVYNVD QRDTDMDGVG DQCDNCPLEH 840
NPDQLDSDSD RIGDTCDNNQ DIDEDGHQNN LDNCPYVPNA NQADHDKDGK GDACDHDDDN 900
DGIPDDKDNC RLVPNPDQKD SDGDGRGDAC KDDFDHDSVP DIDDICPENV DISETDFRRF 960
QMIPLDPKGT SQNDPNWVVR HQGKELVQTV NCDPGLAVGY DEFNAVDFSG TFFINTERDD 1020
DYAGFVFGYQ SSSRFYVVMW KQVTQSYWDT NPTRAQGYSG LSVKVVNSTT GPGEHLRNAL 1080
WHTGNTPGQV RTLWHDPRHI GWKDFTAYRW RLSHRPKTGF IRVVMYEGKK IMADSGPIYD 1140
KTYAGGRLGL FVFSQEMVFF SDLKYECRDP 1170 
Gene Ontology
 GO:0009897; C:external side of plasma membrane; IDA:BHF-UCL.
 GO:0031012; C:extracellular matrix; TAS:BHF-UCL.
 GO:0070062; C:extracellular vesicular exosome; IDA:UniProtKB.
 GO:0005577; C:fibrinogen complex; IDA:BHF-UCL.
 GO:0031093; C:platelet alpha granule lumen; TAS:Reactome.
 GO:0005509; F:calcium ion binding; NAS:BHF-UCL.
 GO:0070052; F:collagen V binding; IDA:BHF-UCL.
 GO:0070051; F:fibrinogen binding; IDA:BHF-UCL.
 GO:0017134; F:fibroblast growth factor binding; IDA:BHF-UCL.
 GO:0001968; F:fibronectin binding; IDA:BHF-UCL.
 GO:0008201; F:heparin binding; IDA:BHF-UCL.
 GO:0042802; F:identical protein binding; NAS:BHF-UCL.
 GO:0005178; F:integrin binding; IMP:BHF-UCL.
 GO:0043236; F:laminin binding; IDA:BHF-UCL.
 GO:0030169; F:low-density lipoprotein particle binding; IDA:BHF-UCL.
 GO:0001786; F:phosphatidylserine binding; IDA:UniProtKB.
 GO:0043394; F:proteoglycan binding; TAS:BHF-UCL.
 GO:0050431; F:transforming growth factor beta binding; ISS:BHF-UCL.
 GO:0000187; P:activation of MAPK activity; IMP:BHF-UCL.
 GO:0007155; P:cell adhesion; NAS:BHF-UCL.
 GO:0007050; P:cell cycle arrest; IDA:BHF-UCL.
 GO:0016477; P:cell migration; IDA:BHF-UCL.
 GO:0034605; P:cellular response to heat; NAS:BHF-UCL.
 GO:0002544; P:chronic inflammatory response; IEP:BHF-UCL.
 GO:0003197; P:endocardial cushion development; IEA:Compara.
 GO:0043652; P:engulfment of apoptotic cell; IDA:BHF-UCL.
 GO:0003417; P:growth plate cartilage development; IEA:Compara.
 GO:0006955; P:immune response; IEP:BHF-UCL.
 GO:0016525; P:negative regulation of angiogenesis; IDA:UniProtKB.
 GO:0002581; P:negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; IDA:BHF-UCL.
 GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB.
 GO:0043537; P:negative regulation of blood vessel endothelial cell migration; IDA:BHF-UCL.
 GO:0010754; P:negative regulation of cGMP-mediated signaling; IDA:BHF-UCL.
 GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:UniProtKB.
 GO:0002605; P:negative regulation of dendritic cell antigen processing and presentation; IDA:BHF-UCL.
 GO:0001937; P:negative regulation of endothelial cell proliferation; IDA:BHF-UCL.
 GO:0051918; P:negative regulation of fibrinolysis; IDA:BHF-UCL.
 GO:0040037; P:negative regulation of fibroblast growth factor receptor signaling pathway; IDA:BHF-UCL.
 GO:0051895; P:negative regulation of focal adhesion assembly; TAS:BHF-UCL.
 GO:0032695; P:negative regulation of interleukin-12 production; IDA:BHF-UCL.
 GO:0010751; P:negative regulation of nitric oxide mediated signal transduction; IDA:BHF-UCL.
 GO:0010748; P:negative regulation of plasma membrane long-chain fatty acid transport; IDA:BHF-UCL.
 GO:0010757; P:negative regulation of plasminogen activation; IDA:BHF-UCL.
 GO:0003151; P:outflow tract morphogenesis; IEA:Compara.
 GO:0018149; P:peptide cross-linking; IDA:BHF-UCL.
 GO:0030168; P:platelet activation; TAS:Reactome.
 GO:0002576; P:platelet degranulation; TAS:Reactome.
 GO:0045766; P:positive regulation of angiogenesis; IMP:BHF-UCL.
 GO:0043536; P:positive regulation of blood vessel endothelial cell migration; IDA:BHF-UCL.
 GO:0010811; P:positive regulation of cell-substrate adhesion; IEA:Compara.
 GO:2000353; P:positive regulation of endothelial cell apoptotic process; IDA:UniProtKB.
 GO:1900119; P:positive regulation of execution phase of apoptosis; IDA:UniProtKB.
 GO:0010763; P:positive regulation of fibroblast migration; IDA:BHF-UCL.
 GO:0043032; P:positive regulation of macrophage activation; IDA:BHF-UCL.
 GO:0010759; P:positive regulation of macrophage chemotaxis; ISS:BHF-UCL.
 GO:0051897; P:positive regulation of protein kinase B signaling cascade; IDA:UniProtKB.
 GO:2000379; P:positive regulation of reactive oxygen species metabolic process; IDA:BHF-UCL.
 GO:0030511; P:positive regulation of transforming growth factor beta receptor signaling pathway; IDA:BHF-UCL.
 GO:0032914; P:positive regulation of transforming growth factor beta1 production; ISS:BHF-UCL.
 GO:0045727; P:positive regulation of translation; IDA:BHF-UCL.
 GO:0042535; P:positive regulation of tumor necrosis factor biosynthetic process; IDA:UniProtKB.
 GO:0051592; P:response to calcium ion; IDA:BHF-UCL.
 GO:0042493; P:response to drug; IEP:UniProtKB.
 GO:0009749; P:response to glucose stimulus; IDA:BHF-UCL.
 GO:0001666; P:response to hypoxia; NAS:BHF-UCL.
 GO:0032026; P:response to magnesium ion; IDA:BHF-UCL.
 GO:0032570; P:response to progesterone stimulus; TAS:BHF-UCL.
 GO:0002040; P:sprouting angiogenesis; IMP:BHF-UCL. 
Interpro
 IPR008985; ConA-like_lec_gl_sf.
 IPR013320; ConA-like_subgrp.
 IPR000742; EG-like_dom.
 IPR001881; EGF-like_Ca-bd.
 IPR013032; EGF-like_CS.
 IPR001791; Laminin_G.
 IPR000884; Thrombospondin_1_rpt.
 IPR003367; Thrombospondin_3-like_rpt.
 IPR017897; Thrombospondin_3_rpt.
 IPR008859; Thrombospondin_C.
 IPR001007; VWF_C. 
Pfam
 PF07645; EGF_CA
 PF00090; TSP_1
 PF02412; TSP_3
 PF05735; TSP_C
 PF00093; VWC 
SMART
 SM00181; EGF
 SM00209; TSP1
 SM00210; TSPN
 SM00214; VWC 
PROSITE
 PS00022; EGF_1
 PS01186; EGF_2
 PS50026; EGF_3
 PS50025; LAM_G_DOMAIN
 PS50092; TSP1
 PS51234; TSP3
 PS51236; TSP_CTER
 PS01208; VWFC_1
 PS50184; VWFC_2 
PRINTS