UniProt Accession

 BIN2_MOUSE; D3Z6Q9 

Genbank Protein ID

 AC123724 

Genbank Nucleotide ID

  

Protein Name

 Bridging integrator 2 

Protein Synonyms/Alias

  

Gene Name

 Bin2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
27	KFSRAQEKVLQKLGK	acetylation	[1]
145	RIAKRGRKLVDYDSA	acetylation	[2]
145	RIAKRGRKLVDYDSA	ubiquitination	[3]

Reference

 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Inhibits phagocytosis (By similarity). Plays a role in podosome formation. 

Sequence Annotation

 DOMAIN 28 244 BAR.
 MOD_RES 273 273 Phosphoserine (By similarity).
 MOD_RES 357 357 Phosphoserine (By similarity).
 MOD_RES 424 424 Phosphoserine (By similarity).
 MOD_RES 439 439 Phosphoserine (By similarity).  

Keyword

 Cell junction; Cell membrane; Cell projection; Complete proteome; Cytoplasm; Membrane; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 489 AA 

Protein Sequence

Gene Ontology

 GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0042995; C:cell projection; IEA:UniProtKB-KW.
 GO:0001891; C:phagocytic cup; IEA:UniProtKB-SubCell.
 GO:0002102; C:podosome; ISS:UniProtKB.
 GO:0005543; F:phospholipid binding; ISS:UniProtKB.
 GO:0060326; P:cell chemotaxis; ISS:UniProtKB.
 GO:0097320; P:membrane tubulation; ISS:UniProtKB.
 GO:0071800; P:podosome assembly; ISS:UniProtKB. 

Interpro

 IPR027267; AH/BAR-dom.
 IPR003005; Amphiphysin.
 IPR004148; BAR_dom. 

Pfam

 PF03114; BAR 

SMART

 SM00721; BAR 

PROSITE

 PS51021; BAR 

PRINTS

 PR01251; AMPHIPHYSIN.