CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023828
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Probable RNA-binding protein 19 
Protein Synonyms/Alias
 RNA-binding motif protein 19 
Gene Name
 RBM19 
Gene Synonyms/Alias
 KIAA0682 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
85KSFGDPAKPRAWSKHacetylation[1, 2, 3, 4]
884GFVDFLTKQDAKRAFubiquitination[5]
Reference
 [1] Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome.
 Morselli E, Mariño G, Bennetzen MV, Eisenberg T, Megalou E, Schroeder S, Cabrera S, Bénit P, Rustin P, Criollo A, Kepp O, Galluzzi L, Shen S, Malik SA, Maiuri MC, Horio Y, López-Otín C, Andersen JS, Tavernarakis N, Madeo F, Kroemer G.
 J Cell Biol. 2011 Feb 21;192(4):615-29. [PMID: 21339330]
 [2] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Plays a role in embryo pre-implantation development (By similarity). 
Sequence Annotation
 DOMAIN 2 79 RRM 1.
 DOMAIN 294 369 RRM 2.
 DOMAIN 402 480 RRM 3.
 DOMAIN 587 659 RRM 4.
 DOMAIN 730 811 RRM 5.
 DOMAIN 832 912 RRM 6.
 MOD_RES 174 174 Phosphoserine.
 MOD_RES 176 176 Phosphoserine.
 MOD_RES 180 180 Phosphoserine.
 MOD_RES 936 936 Phosphoserine.
 MOD_RES 949 949 Phosphoserine.
 MOD_RES 951 951 Phosphoserine.  
Keyword
 3D-structure; Chromosome; Complete proteome; Cytoplasm; Developmental protein; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 960 AA 
Protein Sequence
MSRLIVKNLP NGMKEERFRQ LFAAFGTLTD CSLKFTKDGK FRKFGFIGFK SEEEAQKAQK 60
HFNKSFIDTS RITVEFCKSF GDPAKPRAWS KHAQKPSQPK QPPKDSTTPE IKKDEKKKKV 120
AGQLEKLKED TEFQEFLSVH QRRAQAATWA NDGLDAEPSK GKSKPASDYL NFDSDSGQES 180
EEEGAGEDLE EEASLEPKAA VQKELSDMDY LKSKMVKAGS SSSSEEEESE DEAVHCDEGS 240
EAEEEDSSAT PVLQERDSKG AGQEQGMPAG KKRPPEARAE TEKPANQKEP TTCHTVKLRG 300
APFNVTEKNV MEFLAPLKPV AIRIVRNAHG NKTGYIFVDF SNEEEVKQAL KCNREYMGGR 360
YIEVFREKNV PTTKGAPKNT TKSWQGRILG ENEEEEDLAE SGRLFVRNLP YTSTEEDLEK 420
LFSKYGPLSE LHYPIDSLTK KPKGFAFITF MFPEHAVKAY SEVDGQVFQG RMLHVLPSTI 480
KKEASEDASA LGSSSYKKKK EAQDKANSAS SHNWNTLFMG PNAVADAIAQ KYNATKSQVF 540
DHETKGSVAV RVALGETQLV QEVRRFLIDN GVSLDSFSQA AAERSKTVIL VKNLPAGTLA 600
AQLQETFGHF GSLGRVLLPE GGITAIVEFL EPLEARKAFR HLAYSKFHHV PLYLEWAPVG 660
VFSSTAPQKK KLQDTPSEPM EKDPAEPETV PDGETPEDEN PTEEGADNSS AKMEEEEEEE 720
EEEEESLPGC TLFIKNLNFD TTEEKLKEVF SKVGTVKSCS ISKKKNKAGV LLSMGFGFVE 780
YRKPEQAQKA LKQLQGHVVD GHKLEVRISE RATKPAVTLA RKKQVPRKQT TSKILVRNIP 840
FQAHSREIRE LFSTFGELKT VRLPKKMTGT GTHRGFGFVD FLTKQDAKRA FNALCHSTHL 900
YGRRLVLEWA DSEVTLQALR RKTAAHFHEP PKKKRSVVLD EILEQLEGSD SDSEEQTLQL 960 
Gene Ontology
 GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0005730; C:nucleolus; IDA:UniProtKB.
 GO:0005654; C:nucleoplasm; ISS:UniProtKB.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
 GO:0040019; P:positive regulation of embryonic development; ISS:UniProtKB. 
Interpro
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 
Pfam
 PF00076; RRM_1 
SMART
 SM00360; RRM 
PROSITE
 PS50102; RRM 
PRINTS