CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038011
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Receptor tyrosine-protein kinase erbB-4 
Protein Synonyms/Alias
  
Gene Name
 Erbb4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
1189SLLSVPEKAKKAFDNacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1265 AA 
Protein Sequence
SVCAGTENKL SSLSDLEQQY RALRKYYENC EVVMGNLEIT SIEHNRDLSF LRSIREVTGY 60
VLVALNQFRY LPLENLRIIR GTKLYEDRYA LAIFLNYRKD GNFGLQELGL KNLTEILNGG 120
VYVDQNKFLC YADTIHWQDI VRNPWPSNMT LVSTIGSSGC GRCHKSCTGR CWGPTENHCQ 180
TLTRTVCAEQ CDGRCYGPYV SDCCHRECAG GCSGPKDTDC FACMNFNDSG ACVTQCPQTF 240
VYNPTTFQLE HNFNAKYTYG AFCVKKCPHN FVVDSSSCVR ACPSSKMEVE ENGIKMCKPC 300
TDICPKACDG IGTGSLMSAQ TVDSNIDKFI NCTKINGNLI FLVTGIHGDP YNAIDAIDPE 360
KLNVFRTVRE ITGFLNIQSW PPNMTDFSVF SNLVTIGGRV LYSGLSLLIL KQQGITSLQF 420
QSLKEISAGN IYITDNSNLC YYHTINWTTL FSTVNQRIVI RDNRRAENCT AEGMVCNHLC 480
SNDGCWGPGP DQCLSCRRFS RGKICIESCN LYDGEFREFE NGSICVECDS QCEKMEDGLL 540
TCHGPGPDNC TKCSHFKDGP NCVEKCPDGL QGANSFIFKY ADQDRECHPC HPNCTQGCNG 600
PTSHDCIYYP WTGHSTLPQH ARTPLIAAGV IGGLFILVIM ALTFAVYVRR KSIKKKRALR 660
RFLETELVEP LTPSGTAPNQ AQLRILKETE LKRVKVLGSG AFGTVYKGIW VPEGETVKIP 720
VAIKILNETT GPKANVEFMD EALIMASVDH PHLVRLLGVC LSPTIQLVTQ LMPHGCLLEY 780
VHEHKDNIGS QLLLNWCVQI AKGMMYLEER RLVHRDLAAR NVLVKSPNHV KITDFGLARL 840
LEGDEKEYNA DGGKMPIKWM ALECIHYRKF THQSDVWSYG VTIWELMTFG GKPYDGIPTR 900
EIPDLLEKGE RLPQPPICTI DVYMVMVKCW MIDADSRPKF KELAAEFSRM ARDPQRYLVI 960
QGDDRMKLPS PNDSKFFQNL LDEEDLEDMM DAEEYLVPQA FNIPPPIYTS RTRIDSNRNQ 1020
FVYQDGGFAT QQGMPMPYRA TTSTIPEAPV AQGATAEMFD DSCCNGTLRK PVVPHVQEDS 1080
STQRYSADPT VFAPERNPRA ELDEEGYMTP MHDKPKQEYL NPVEENPFVS RRKNGDLQAL 1140
DNPEYHSASS GPPKAEDEYV NEPLYLNTFT NALGNAEYMK NSLLSVPEKA KKAFDNPDYW 1200
NHSLPPRSTL QHPDYLQEYS TKYFYKQNGR IRPIVAENPE YLSEFSLKPG TMLPPPPYRH 1260
RNTVV 1265 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004716; F:receptor signaling protein tyrosine kinase activity; IEA:InterPro.
 GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:InterPro.
 GO:0023014; P:signal transduction by phosphorylation; IEA:GOC.
 GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro. 
Interpro
 IPR000494; EGF_rcpt_L.
 IPR006211; Furin-like_Cys-rich_dom.
 IPR006212; Furin_repeat.
 IPR009030; Growth_fac_rcpt_N_dom.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
 IPR008266; Tyr_kinase_AS.
 IPR020635; Tyr_kinase_cat_dom.
 IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt. 
Pfam
 PF00757; Furin-like
 PF07714; Pkinase_Tyr
 PF01030; Recep_L_domain 
SMART
 SM00261; FU
 SM00219; TyrKc 
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00109; PROTEIN_KINASE_TYR 
PRINTS
 PR00109; TYRKINASE.