UniProt Accession

 CH1B1_MOUSE; Q99LU0; Q3UB77; Q9CXR5 

Genbank Protein ID

 AK014091; AK151071; CT010307; BC002229 

Genbank Nucleotide ID

 BAB29150.2; BAE30087.1; CAJ18515.1; AAH02229.1 

Protein Name

 Charged multivesicular body protein 1b-1 

Protein Synonyms/Alias

 Chromatin-modifying protein 1b-1; CHMP1b-1 

Gene Name

 Chmp1b1 

Gene Synonyms/Alias

 Chmp1b 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
6	**MSNMEKHLFNLKF	acetylation	[1]
6	**MSNMEKHLFNLKF	ubiquitination	[2]
16	FNLKFAAKELNRSSK	acetylation	[1]
42	KIKKAIQKGNMEVAR	ubiquitination	[2]
87	QTAVTMGKVTKSMAG	ubiquitination	[2]
90	VTMGKVTKSMAGVVK	ubiquitination	[2]
97	KSMAGVVKSMDATLK	ubiquitination	[2]
110	LKSMNLEKISALMDK	ubiquitination	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT- III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B and SPAST to the midbody of dividing cells (By similarity). 

Sequence Annotation

 REGION 132 156 Interaction with IST1 (By similarity).
 REGION 174 199 Interaction with SPAST (By similarity).
 REGION 180 199 Interaction with VTA1 (By similarity).
 REGION 180 196 Interaction with VPS4A, MITD1 and STAMBP
 REGION 183 199 Interaction with VPS4B (By similarity).
 MOTIF 186 196 MIT-interacting motif.  

Keyword

 Cell cycle; Cell division; Coiled coil; Complete proteome; Cytoplasm; Direct protein sequencing; Endosome; Membrane; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 199 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 

Interpro

 IPR005024; Snf7. 

Pfam

 PF03357; Snf7 

SMART

  

PROSITE

  

PRINTS