CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008054
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 pH-response regulator protein palH/RIM21 
Protein Synonyms/Alias
 Regulator of IME2 protein 21 
Gene Name
 RIM21 
Gene Synonyms/Alias
 PAL2; YNL294C; N0466 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
363QQDYRFAKYALRVQNubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, VillĂ©n J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301
Functional Description
 Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH (By similarity). Required for growth at alkaline pH. 
Sequence Annotation
 MOD_RES 409 409 Phosphoserine.  
Keyword
 Cell membrane; Complete proteome; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 533 AA 
Protein Sequence
MNLWRHSPEE LAAYNSCHPM KLGSGVLIQL PLYDNSAVYA EDITFRSFCC ERVPVYVSTV 60
LRNSSPYRYL DEVINDWQKF IQVSDYVGGS AEYAIYAVIL SITSNFVITV FLTVICCINI 120
SGRAYKRILQ LLRIASLLAS LNLTIFITKV LRRLEKEHNV YGVVRAHSIM HIFSDDMTFV 180
VLDFLATLMF QFCQVGIVIR LFQRAQEKRI IFFIGVILTI TANILWVIPP FANHTTKHRN 240
DWQILRPFVY LFRIAIATSY ASIVIYHIWQ KKKLWFKFNQ MGLLTLLTIL VVLLLPGFFL 300
ADVSNLWISE LGEVFNTTCY VTSTVITWEW LDRLNVLERK EEAQSILGRP IFEEEQQDYR 360
FAKYALRVQN ALTRRESQDA STDRHDTSSN SEVCDLQTIS RYDPEDQISV GRSIDRMHFN 420
DRGTYKDVAL KKLGYARDKI LYFTDQIVQK SVGHNNSSSS KNEKTKQRKA MVRKRLGLDK 480
PGIYIYSTKD VVFNSDEDDD ENAEDEDDDE YEVGSEGNNN SSATFTSDHI GHI 533 
Gene Ontology
 GO:0016021; C:integral to membrane; ISM:SGD.
 GO:0005886; C:plasma membrane; IDA:SGD.
 GO:0030437; P:ascospore formation; IMP:SGD.
 GO:0071469; P:cellular response to alkalinity; IMP:SGD.
 GO:0009272; P:fungal-type cell wall biogenesis; IMP:SGD.
 GO:0001403; P:invasive growth in response to glucose limitation; IMP:SGD. 
Interpro
 IPR014844; PalH. 
Pfam
 PF08733; PalH 
SMART
  
PROSITE
  
PRINTS