UniProt Accession

 PXK_HUMAN; Q7Z7A4; Q3BCH4; Q3BCH5; Q3BCH6; Q3BDW1; Q45L83; Q59EX3; Q6PK17; Q6ZN39; Q96CA3; Q96R07; Q9NXB8 

Genbank Protein ID

 DQ124707; DQ124708; AY437879; AY847222; AY847220; AY847221; AF399753; AY274811; AB209688; AK000342; AK131385; BC008943; BC014479 

Genbank Nucleotide ID

 AAZ38821.1; AAZ38822.1; AAR98521.1; AAX73354.1; AAX73352.1; AAX73353.1; AAK94455.1; AAP42076.1; BAD92925.1; BAA91097.1; BAD18536.1; AAH08943.1; AAH14479.1 

Protein Name

 PX domain-containing protein kinase-like protein 

Protein Synonyms/Alias

 Modulator of Na,K-ATPase; MONaKA 

Gene Name

 PXK 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
6	**MAFMEKPPAGKVL	ubiquitination	[1]
117	SNCELVKKFLDPNNY	ubiquitination	[1]
187	WADLGPDKYLSDKDF	ubiquitination	[2, 3]
231	LIRMFNEKGTLKDLI	ubiquitination	[1]
235	FNEKGTLKDLIYKAK	ubiquitination	[1]
406	VLLTTSEKPQFKIPT	ubiquitination	[1]
435	KRLIEEQKQIHQHRR	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity. 

Sequence Annotation

 DOMAIN 14 126 PX.
 DOMAIN 88 481 Protein kinase.
 DOMAIN 548 567 WH2.  

Keyword

 Actin-binding; Alternative splicing; Cell membrane; Complete proteome; Cytoplasm; Membrane; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 578 AA 

Protein Sequence

Gene Ontology

 GO:0005813; C:centrosome; IDA:HPA.
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; ISS:UniProtKB.
 GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
 GO:0008022; F:protein C-terminus binding; ISS:UniProtKB.
 GO:0016772; F:transferase activity, transferring phosphorus-containing groups; IEA:InterPro.
 GO:0007154; P:cell communication; IEA:InterPro.
 GO:0006954; P:inflammatory response; IMP:UniProtKB.
 GO:0032780; P:negative regulation of ATPase activity; IEA:Compara.
 GO:0043271; P:negative regulation of ion transport; IEA:Compara.
 GO:0050804; P:regulation of synaptic transmission; ISS:UniProtKB. 

Interpro

 IPR011009; Kinase-like_dom.
 IPR001683; Phox.
 IPR000719; Prot_kinase_cat_dom.
 IPR003124; WH2_dom. 

Pfam

 PF00069; Pkinase
 PF00787; PX
 PF02205; WH2 

SMART

 SM00312; PX 

PROSITE

 PS50011; PROTEIN_KINASE_DOM
 PS50195; PX
 PS51082; WH2 

PRINTS