CPLM-020227

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-020227

UniProt Accession

MECR_HUMAN; Q9BV79; B3KT72; Q5SYU0; Q5SYU1; Q5SYU2; Q6IBU9; Q9Y373

Genbank Protein ID

AF151821; AK095099; CR456703; AL590729; AL590729; CH471059; BC001419

Genbank Nucleotide ID

AAD34058.1; BAG52984.1; CAG32984.1; CAI14329.1; CAI14330.1; EAX07655.1; AAH01419.1

Protein Name

Trans-2-enoyl-CoA reductase, mitochondrial

Protein Synonyms/Alias

Nuclear receptor-binding factor 1; HsNrbf-1; NRBF-1

Gene Name

MECR

Gene Synonyms/Alias

NBRF1; CGI-63

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
223	RDRPDIQKLSDRLKS	ubiquitination	[1]
267	ALNCVGGKSSTELLR	ubiquitination	[1]

Reference

[1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]

Functional Description

Catalyzes the reduction of trans-2-enoyl-CoA to acyl-CoA with chain length from C6 to C16 in an NADPH-dependent manner with preference to medium chain length substrate. May have a role in the mitochondrial synthesis of fatty acids.

Sequence Annotation

Keyword

3D-structure; Alternative splicing; Complete proteome; Fatty acid biosynthesis; Fatty acid metabolism; Lipid biosynthesis; Lipid metabolism; Mitochondrion; NADP; Oxidoreductase; Polymorphism; Reference proteome; Transit peptide.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

373 AA

Protein Sequence

MWVCSTLWRV RTPARQWRGL LPASGCHGPA ASSYSASAEP ARVRALVYGH HGDPAKVVEL 60
KNLELAAVRG SDVRVKMLAA PINPSDINMI QGNYGFLPEL PAVGGNEGVA QVVAVGSNVT 120
GLKPGDWVIP ANAGLGTWRT EAVFSEEALI QVPSDIPLQS AATLGVNPCT AYRMLMDFEQ 180
LQPGDSVIQN ASNSGVGQAV IQIAAALGLR TINVVRDRPD IQKLSDRLKS LGAEHVITEE 240
ELRRPEMKNF FKDMPQPRLA LNCVGGKSST ELLRQLARGG TMVTYGGMAK QPVVASVSLL 300
IFKDLKLRGF WLSQWKKDHS PDQFKELILT LCDLIRRGQL TAPACSQVPL QDYQSALEAS 360
MKPFISSKQI LTM 373

Gene Ontology

GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0019166; F:trans-2-enoyl-CoA reductase (NADPH) activity; IDA:UniProtKB.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
GO:0006631; P:fatty acid metabolic process; IDA:UniProtKB.

Interpro

IPR013149; ADH_C.
IPR013154; ADH_GroES-like.
IPR002085; ADH_SF_Zn-type.
IPR011032; GroES-like.
IPR016040; NAD(P)-bd_dom.

Pfam

PF08240; ADH_N
PF00107; ADH_zinc_N

SMART

PROSITE

PRINTS