UniProt Accession

 PPIE_BOVIN; A4FV72 

Genbank Protein ID

 BC123818 

Genbank Nucleotide ID

 AAI23819.1 

Protein Name

 Peptidyl-prolyl cis-trans isomerase E 

Protein Synonyms/Alias

 PPIase E; Cyclophilin E; Rotamase E 

Gene Name

 PPIE 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Bos taurus (Bovine) 

NCBI Taxa ID

 9913 

Lysine Modification

Position	Peptide	Type	References
83	TIRVNLAKPMRIKEG	ubiquitination	[1, 2]
212	NHNGTGGKSIYGKKF	ubiquitination	[1]
218	GKSIYGKKFDDENFI	ubiquitination	[3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Combines RNA-binding and PPIase activities. May be involved in pre-mRNA splicing (By similarity). 

Sequence Annotation

 DOMAIN 5 83 RRM.
 DOMAIN 143 299 PPIase cyclophilin-type.  

Keyword

 Complete proteome; Isomerase; mRNA processing; mRNA splicing; Nucleus; Reference proteome; RNA-binding; Rotamase; Spliceosome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 301 AA 

Protein Sequence

Gene Ontology

 GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:UniProtKB-KW.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0006457; P:protein folding; IEA:UniProtKB-KW.
 GO:0000413; P:protein peptidyl-prolyl isomerization; IEA:GOC.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. 

Interpro

 IPR002130; Cyclophilin-like_PPIase_dom.
 IPR020892; Cyclophilin-type_PPIase_CS.
 IPR016304; Cyclophilin-type_PPIase_E.
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 

Pfam

 PF00160; Pro_isomerase
 PF00076; RRM_1 

SMART

 SM00360; RRM 

PROSITE

 PS00170; CSA_PPIASE_1
 PS50072; CSA_PPIASE_2
 PS50102; RRM 

PRINTS

 PR00153; CSAPPISMRASE.