CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007213
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Casein kinase I homolog 3 
Protein Synonyms/Alias
  
Gene Name
 YCK3 
Gene Synonyms/Alias
 CKI3; YER123W 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
325ALRLNDLKDDGHYDWubiquitination[1]
462FVPYSSSKANPKRSNubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. 
Sequence Annotation
 DOMAIN 14 319 Protein kinase.
 NP_BIND 20 28 ATP (By similarity).
 MOTIF 444 447 YXXZ targeting signal.
 ACT_SITE 150 150 Proton acceptor (By similarity).
 BINDING 60 60 ATP (By similarity).
 LIPID 517 517 S-palmitoyl cysteine (Probable).
 LIPID 518 518 S-palmitoyl cysteine (Probable).
 LIPID 519 519 S-palmitoyl cysteine (Probable).
 LIPID 520 520 S-palmitoyl cysteine (Probable).
 LIPID 522 522 S-palmitoyl cysteine (Probable).
 LIPID 523 523 S-palmitoyl cysteine (Probable).
 LIPID 524 524 S-palmitoyl cysteine (Probable).  
Keyword
 ATP-binding; Cell membrane; Complete proteome; Kinase; Lipoprotein; Membrane; Nucleotide-binding; Nucleus; Palmitate; Reference proteome; Serine/threonine-protein kinase; Transferase; Vacuole. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 524 AA 
Protein Sequence
MSQRSSQHIV GIHYAVGPKI GEGSFGVIFE GENILHSCQA QTGSKRDSSI IMANEPVAIK 60
FEPRHSDAPQ LRDEFRAYRI LNGCVGIPHA YYFGQEGMHN ILIIDLLGPS LEDLFEWCGR 120
KFSVKTTCMV AKQMIDRVRA IHDHDLIYRD IKPDNFLISQ YQRISPEGKV IKSCASSSNN 180
DPNLIYMVDF GMAKQYRDPR TKQHIPYRER KSLSGTARYM SINTHFGREQ SRRDDLESLG 240
HVFFYFLRGS LPWQGLKAPN NKLKYEKIGM TKQKLNPDDL LLNNAIPYQF ATYLKYARSL 300
KFDEDPDYDY LISLMDDALR LNDLKDDGHY DWMDLNGGKG WNIKINRRAN LHGYGNPNPR 360
VNGNTARNNV NTNSKTRNTT PVATPKQQAQ NSYNKDNSKS RISSNPQSFT KQQHVLKKIE 420
PNSKYIPETH SNLQRPIKSQ SQTYDSISHT QNSPFVPYSS SKANPKRSNN EHNLPNHYTN 480
LANKNINYQS QRNYEQENDA YSDDENDTFC SKIYKYCCCC FCCC 524 
Gene Ontology
 GO:0000329; C:fungal-type vacuole membrane; IDA:SGD.
 GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0005886; C:plasma membrane; IDA:SGD.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004674; F:protein serine/threonine kinase activity; ISS:SGD.
 GO:0016192; P:vesicle-mediated transport; IMP:SGD. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00069; Pkinase 
SMART
  
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS