CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032795
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Biotin requiring domain-containing protein / 2-oxo acid dehydrogenases acyltransferase catalytic domain-containing protein, putative 
Protein Synonyms/Alias
  
Gene Name
 TGVEG_000210 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Toxoplasma gondii 
NCBI Taxa ID
 5811 
Lysine Modification
Position
Peptide
Type
References
147PALSSTMKEGKVVTWacetylation[1]
150SSTMKEGKVVTWSKQacetylation[2]
492SRTAAFMKHGQALARacetylation[1, 2]
576PAPPPYLKRAVSTYGacetylation[1, 2]
917SHAAAFLKDFASLLEacetylation[2]
Reference
 [1] Lysine acetylation is widespread on proteins of diverse function and localization in the protozoan parasite Toxoplasma gondii.
 Jeffers V, Sullivan WJ Jr.
 Eukaryot Cell. 2012 Jun;11(6):735-42. [PMID: 22544907]
 [2] Protein intrinsic disorder in the acetylome of intracellular and extracellular Toxoplasma gondii.
 Xue B, Jeffers V, Sullivan WJ, Uversky VN.
 Mol Biosyst. 2013 Apr 5;9(4):645-57. [PMID: 23403842] 
Functional Description
  
Sequence Annotation
  
Keyword
 Acyltransferase; Complete proteome; Lipoyl; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 932 AA 
Protein Sequence
MALPSPGILV HVSLFLAAVS SAFGLQLVPS SSPAPSASST SFSGSSAPAF VAPAVSSGSG 60
VHSTRPRFFA SPSASSASSV SSTNAGQRPL SAGSSLQTRE RRCGSRLTSS PLCAAEGTVR 120
RQETAVGSSL RGAVQEISMP ALSSTMKEGK VVTWSKQVGD RVEPGDVLMV VESDKADMDV 180
EAFDSGFMAM HLVREGDAAP VGTTVALLAE KEEDISLIQA KGLSLISASS SPAADSTPAV 240
TDLLMPSLSP SLKTARMTVW RKKEGEKVNK GDVLFVVESD KADMDVEAPH DGVLAHIAVR 300
EGVTVDVGST VGYLAPSAEV ASAFKNALSD SAAPAAANPS TMPEGAQEIF MPALSSTMTS 360
GKVSKWNKAV GDAVHVGDTL MVVESDKADM DVESFDEGYL AAITVAEGES APVGQTVAII 420
VPSKDDIAKV QDALTAASTA SSSSPAHAPL SSASSPSTPS SRLSSSDSVS VSSSQSGRPT 480
TGGDSRTAAF MKHGQALARW TSPSVDQDVK DQLPEGLTGN DLQQEWLQRI EATMPTTFAA 540
LQANPQMQKA LLERLNLRVP PPHTLRVSPA PPPYLKRAVS TYGAATAGAP DTRASGIDRT 600
SRGPARDPSG QPLATFNAIE LAKKNKLNLE EVKGTGTNRR ITAADVRQHL HLPSDEATVV 660
TSKREKEGKI ESLGVPPPGS VPLDAMQKAV ARNMEATMDV PVFRVSRGIY VDKLEAMVQE 720
LKQIVAEQNA AAIAAEGPDA PQQSTVTMSV LLAKAVALTL EKHPIMNAAY NPKDGGQIQY 780
VPHPGAVNVA MAVSVDGGLL TPVLRNVNTK SVFELSADWA VLVDKARKRR LTAEENSAGT 840
FYISNLGMFG VSQFDAVLPK GVGTIMAVGG TESVPFFPKT GTLDAPAGNP SVRRRMTVTI 900
TADHRHIYGS HAAAFLKDFA SLLETRPSAL LI 932 
Gene Ontology
 GO:0043754; F:dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity; IEA:EC.
 GO:0004742; F:dihydrolipoyllysine-residue acetyltransferase activity; IEA:EC. 
Interpro
 IPR003016; 2-oxoA_DH_lipoyl-BS.
 IPR001078; 2-oxoacid_DH_actylTfrase.
 IPR000089; Biotin_lipoyl.
 IPR023213; CAT-like_dom.
 IPR004167; E3-bd.
 IPR011053; Single_hybrid_motif. 
Pfam
 PF00198; 2-oxoacid_dh
 PF00364; Biotin_lipoyl
 PF02817; E3_binding 
SMART
  
PROSITE
 PS50968; BIOTINYL_LIPOYL
 PS00189; LIPOYL 
PRINTS