UniProt Accession

 Q57Z31_TRYB2; Q57Z31; D6XH01 

Genbank Protein ID

 AC116668; AC116668; AC116668; AC116668; AC116668; AC116668; AC116668; AC116668; AC116668; AC116668; CP000068; CP000068; CP000068; CP000068; CP000068; CP000068; CP000068; CP000068; CP000068; CP000068 

Genbank Nucleotide ID

 AAX80575.1; AAX80576.1; AAX80618.1; AAX80619.1; AAX80620.1; AAX80621.1; AAX80622.1; AAX80623.1; AAX80624.1; AAX80625.1; AAZ11528.1; AAZ11529.1; AAZ11530.1; AAZ11531.1; AAZ11532.1; AAZ11533.1; AAZ11534.1; AAZ11535.1; AAZ11536.1; AAZ11537.1 

Protein Name

 Histone H4 

Protein Synonyms/Alias

  

Gene Name

 Tb927.5.4170, Tb927.5.4180, Tb927.5.4190, Tb927.5.4200,Tb927.5.4210, Tb927.5.4220, Tb927.5.4230, Tb927.5.4240, Tb927.5.4250,Tb927.5.4260 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Trypanosoma brucei brucei (strain 927/4 GUTat10.1) 

NCBI Taxa ID

 999953 

Lysine Modification

Position	Peptide	Type	References
3	*****MAKGKKSGEA	acetylation	[1]
5	***MAKGKKSGEAKG	acetylation	[1, 2]
6	**MAKGKKSGEAKGS	acetylation	[1]
11	GKKSGEAKGSQKRQK	acetylation	[1, 3]
15	GEAKGSQKRQKKVLR	acetylation	[1, 2]
18	KGSQKRQKKVLRENV	acetylation	[1]
19	GSQKRQKKVLRENVR	acetylation	[1]

Reference

 [1] Histone modifications in Trypanosoma brucei.
 Mandava V, Fernandez JP, Deng H, Janzen CJ, Hake SB, Cross GA.
 Mol Biochem Parasitol. 2007 Nov;156(1):41-50. [PMID: 17714803]
 [2] Acetylation of histone H4K4 is cell cycle regulated and mediated by HAT3 in Trypanosoma brucei.
 Siegel TN, Kawahara T, Degrasse JA, Janzen CJ, Horn D, Cross GA.
 Mol Microbiol. 2008 Feb;67(4):762-71. [PMID: 18179414]
 [3] Two essential MYST-family proteins display distinct roles in histone H4K10 acetylation and telomeric silencing in trypanosomes.
 Kawahara T, Siegel TN, Ingram AK, Alsford S, Cross GA, Horn D.
 Mol Microbiol. 2008 Aug;69(4):1054-68. [PMID: 18631159] 

Functional Description

 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). 

Sequence Annotation

  

Keyword

 Chromosome; Complete proteome; DNA-binding; Nucleosome core; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 100 AA 

Protein Sequence

Gene Ontology

 GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; IEA:UniProtKB-KW.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0006334; P:nucleosome assembly; IEA:InterPro. 

Interpro

 IPR009072; Histone-fold.
 IPR007125; Histone_core_D.
 IPR001951; Histone_H4. 

Pfam

 PF00125; Histone 

SMART

 SM00417; H4 

PROSITE

  

PRINTS

 PR00623; HISTONEH4.