| Tag | Content |
|---|
| CPLM ID | CPLM-017208 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Complement component C8 alpha chain |
Protein Synonyms/Alias | Complement component 8 subunit alpha |
Gene Name | C8a |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 204 | LYYGEDEKYFRKPYN | ubiquitination | [1] | | 258 | TVGVAPVKSPVSIEV | ubiquitination | [1] | | 271 | EVTGSGSKASSFLNK | ubiquitination | [1] | | 363 | VLDKEKMKTEGTTVD | ubiquitination | [1] | | 537 | RTVIEGLKDFKAAGH | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself (By similarity). |
Sequence Annotation | DOMAIN 38 91 TSP type-1 1.
DOMAIN 94 132 LDL-receptor class A.
DOMAIN 136 498 MACPF.
DOMAIN 499 529 EGF-like.
DOMAIN 542 586 TSP type-1 2.
CARBOHYD 44 44 C-linked (Man) (By similarity).
CARBOHYD 437 437 N-linked (GlcNAc...) (Potential).
CARBOHYD 545 545 C-linked (Man) (By similarity).
CARBOHYD 548 548 C-linked (Man) (By similarity).
CARBOHYD 551 551 C-linked (Man) (By similarity).
DISULFID 39 74 By similarity.
DISULFID 50 53 By similarity.
DISULFID 84 90 By similarity.
DISULFID 96 108 By similarity.
DISULFID 102 121 By similarity.
DISULFID 115 130 By similarity.
DISULFID 140 177 By similarity.
DISULFID 194 194 Interchain (with C-60 in C8-gamma chain)
DISULFID 375 399 By similarity. |
Keyword | Cell membrane; Complement alternate pathway; Complement pathway; Complete proteome; Cytolysis; Disulfide bond; EGF-like domain; Glycoprotein; Immunity; Innate immunity; Membrane; Membrane attack complex; Polymorphism; Reference proteome; Repeat; Secreted; Signal; Transmembrane; Transmembrane beta strand. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 587 AA |
Protein Sequence | MFVVAFFGLS LVAWHPGVTA QEKVNQRVTR AVTPQAVSCQ LSDWYKWTDC FPCQDKKYRY 60
RSLLQPSKFG GTICSGDIWD EASCDSPTPC LRQAQCGQDF QCRETGRCLK RHLVCNGDND 120
CLDGSDESDC EDVRVTEDDC HQYEPIPGSE RAALGYNILT QEEAQSVYDA KYYGGQCETV 180
YNGDWRKLRY DPTCERLYYG EDEKYFRKPY NFLKYHFEAL ADTSISSEFY DDANDLFFHI 240
KNGKSHSAGV TVGVAPVKSP VSIEVTGSGS KASSFLNKLN KYNEKRYGFM RVSTKIQTAQ 300
FKMRRNNIVL DEGMLQSLME LPEQFNYGMY AKFINDYGTH YITSGTMGGI YEYVMVLDKE 360
KMKTEGTTVD EVQKCIGGGI GIGIKDSTIE GVGISGEFCE NSGDGDRDIR KKITGVEDII 420
SRVQGGSSVW GSVLTHNSSA ITYQSWGRSL KYNPVVIDFE MQPIYQLLRH TNLGPLETKR 480
QNLRRALDQY LMEFNACRCG PCFNNGEPIL DGTNCRCQCS MGRQGLACER TVIEGLKDFK 540
AAGHWSCWSS WSECRGGSQE RRRQCNNPPP KNGGTPCLGR NLQTQAC 587 |
Gene Ontology | GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. GO:0005579; C:membrane attack complex; IEA:UniProtKB-KW. GO:0006957; P:complement activation, alternative pathway; IEA:UniProtKB-KW. GO:0006958; P:complement activation, classical pathway; IEA:UniProtKB-KW. GO:0019835; P:cytolysis; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |