CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001386
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Kinesin-like protein KIF1B 
Protein Synonyms/Alias
  
Gene Name
 Kif1b 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
201DLMDAGNKARTVAATubiquitination[1]
1089RMNDLDLKSGTLLDGubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Motor for anterograde transport of mitochondria. Has a microtubule plus end-directed motility (By similarity). 
Sequence Annotation
 DOMAIN 2 273 Kinesin-motor.
 DOMAIN 556 612 FHA.
 DOMAIN 1701 1799 PH.
 NP_BIND 97 104 ATP (By similarity).
 REGION 270 350 Interaction with KBP (By similarity).
 MOD_RES 1057 1057 Phosphoserine (By similarity).
 MOD_RES 1454 1454 Phosphoserine (By similarity).
 MOD_RES 1487 1487 Phosphoserine (By similarity).
 MOD_RES 1610 1610 Phosphoserine (By similarity).
 MOD_RES 1613 1613 Phosphoserine (By similarity).  
Keyword
 Alternative splicing; ATP-binding; Coiled coil; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Cytoskeleton; Microtubule; Mitochondrion; Motor protein; Nucleotide-binding; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1816 AA 
Protein Sequence
MSGASVKVAV RVRPFNSRET SKESKCIIQM QGNSTSIINP KNPKEAPKSF SFDYSYWSHT 60
SPEDPCFASQ SRVYNDIGKE MLLHAFEGYN VCIFAYGQTG AGKSYTMMGK QEESQAGIIP 120
QLCEELFEKI NDNCNEDMSY SVEVSYMEIY CERVRDLLNP KNKGNLRVRE HPLLGPYVED 180
LSKLAVTSYT DIADLMDAGN KARTVAATNM NETSSRSHAV FTIVFTQKKQ DPETNLSTEK 240
VSKISLVDLA GSERADSTGA KGTRLKEGAN INKSLTTLGK VISALAEVDN CTSKSKKKKK 300
TDFIPYRDSV LTWLLRENLG GNSRTAMVAA LSPADINYDE TLSTLRYADR AKQIKCNAVI 360
NEDPNAKLVR ELKEEVTRLK DLLRAQGLGD IIDIDPLMDD YSGSGGKYLK DFQNNKHRYL 420
LASENQRPGN FSTASMGSLT SSPSSCSLNS QAGLTSVTSI QERIMSTPGG EEAIERLKES 480
EKIIAELNET WEEKLRKTEA IRMEREALLA EMGVAIREDG GTLGVFSPKK TPHLVNLNED 540
PLMSECLLYY IKDGITRVGQ ADAERRQDIV LSGAHIKEEH CIFRSERNNT GEVIVTLEPC 600
ERSETYVNGK RVAHPVQLRS GNRIIMGKNH VFRFNHPEQA RAEREKTPSA ETPSEPVDWT 660
FAQRELLEKQ GIDMKQEMEK RLQEMEILYK REKEEADLLL EQQRLDYESK LQALQKQVET 720
RSLAAETTEE EEEEEEVPWT QHEFELAQWA FRKWKSHQFT SLRDLLWGNA VYLKEANAIS 780
VELKKKVQFQ FVLLTDTLYS PVPPELLPTE MGKTHEDRPF PRTVVAVEVQ DLKNGATHYW 840
SLDKLKQRLD LMREMYDRAG EVGSNAQDDS ETTMTGSDPF YDRFHWFKLV GSSPIFHGCV 900
NERLADRTPS PTFSTADSDI TELADEQQDA MEDFDDEAFV DDTGSDAGTE EGSELFSDGH 960
DPFYDRSPWF ILVGRAFVYL SNLLYPVPLI HRVAIVSEKG EVRGFLRVAV QAIAADEEAP 1020
DYGSGIRQSG TAKISFDNEY FNQSDFPSAA MTRSGLSLEE LRIVEGQGQS SEVISPPEEV 1080
NRMNDLDLKS GTLLDGKMVM EGFSEEIGNH LKLGSAFTFR VTVLQASGIL PEYADIFCQF 1140
NFLHRHDEAF STEPLKNNGR GSPLGFYHVQ NIAVEVTESF VDYIKTKPIV FEVFGHYQQH 1200
PLHLQGQELN SPPQPSRRFF PPPMPLSRPV PATKLNTMNK TSLGQSMSKY DLLVWFEISE 1260
LEPTGEYIPA VVDHTAGLPC QGTFLLHQGI QRRITVTIIH EKGSELHWKD VRELVVGRIR 1320
NKPEVDEAAV DAILSLNIIS AKSLKSSHSS SRTFYRFEAV WDSSLHNSLL LNRVTPYGEK 1380
IYMTLSAYLE LDHCIQPAVI TKDVCMVFYS RDAKISPPRS LRNLFGSGYS KSPDSNRVTG 1440
IYELSLCKMA DTGSPGMQRR RRKVLDTSVA YVRGEENLAG WRPRGDSLIL EHQWELEKLE 1500
LLHEVEKTRH FLLLRERLGD SIPKSMSDSL SPSLSSGTLS TSTSISSQIS TTTFESAITP 1560
SESSGYDSAD IESLVDREKE LATKCLQLLT HTFNREFSQV HGSISDCKLS DISPIGRDPS 1620
VSSFSSSTLT PSSTCPSLVD SRSSSMDQKT PEANSRASSP CQEFEQFQII PTVETPYLAR 1680
AGKNEFLNLV PDIEEVRAGS VVSKKGYLHF KEPLSSNWAK HFVVVRRPYV FIYNSDKDPV 1740
ERGIINLSTA QVEYSEDQQA MLKTPNTFAV CTKHRGVLLQ ALNDKDMNDW LYAFNPLLAG 1800
TIRSKLSRRC PSQPKY 1816 
Gene Ontology
 GO:0030659; C:cytoplasmic vesicle membrane; ISS:UniProtKB.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0005875; C:microtubule associated complex; ISS:UniProtKB.
 GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
 GO:0043005; C:neuron projection; IDA:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016887; F:ATPase activity; ISS:UniProtKB.
 GO:0003777; F:microtubule motor activity; ISS:UniProtKB.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0008089; P:anterograde axon cargo transport; ISS:UniProtKB.
 GO:0047497; P:mitochondrion transport along microtubule; IEA:Compara.
 GO:0007274; P:neuromuscular synaptic transmission; ISS:UniProtKB.
 GO:0007270; P:neuron-neuron synaptic transmission; ISS:UniProtKB. 
Interpro
 IPR000253; FHA_dom.
 IPR022140; KIF1B.
 IPR022164; Kinesin-like.
 IPR019821; Kinesin_motor_CS.
 IPR001752; Kinesin_motor_dom.
 IPR027417; P-loop_NTPase.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR008984; SMAD_FHA_domain. 
Pfam
 PF12473; DUF3694
 PF00498; FHA
 PF12423; KIF1B
 PF00225; Kinesin
 PF00169; PH 
SMART
 SM00240; FHA
 SM00129; KISc
 SM00233; PH 
PROSITE
 PS50006; FHA_DOMAIN
 PS00411; KINESIN_MOTOR_DOMAIN1
 PS50067; KINESIN_MOTOR_DOMAIN2
 PS50003; PH_DOMAIN 
PRINTS
 PR00380; KINESINHEAVY.