UniProt Accession

 SC6A3_MOUSE; Q61327; Q60719; Q9R1I2 

Genbank Protein ID

 AF109072; BC054119; AH003328; U16265 

Genbank Nucleotide ID

 AAD19643.1; AAH54119.1; AAA86462.2; AAC52283.1 

Protein Name

 Sodium-dependent dopamine transporter 

Protein Synonyms/Alias

 DA transporter; DAT; Solute carrier family 6 member 3 

Gene Name

 Slc6a3 

Gene Synonyms/Alias

 Dat; Dat1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
598	AYAITPEKDRQLVDR	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals (By similarity). 

Sequence Annotation

 REGION 560 589 Interaction with TGFB1I1 (By similarity).
 CARBOHYD 181 181 N-linked (GlcNAc...) (Potential).
 CARBOHYD 188 188 N-linked (GlcNAc...) (Potential).
 CARBOHYD 196 196 N-linked (GlcNAc...) (Potential).
 CARBOHYD 204 204 N-linked (GlcNAc...) (Potential).
 DISULFID 305 305 Interchain (By similarity).  

Keyword

 Complete proteome; Disulfide bond; Glycoprotein; Membrane; Neurotransmitter transport; Reference proteome; Symport; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 619 AA 

Protein Sequence

Gene Ontology

 GO:0030424; C:axon; IDA:MGI.
 GO:0005887; C:integral to plasma membrane; IEA:InterPro.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0035240; F:dopamine binding; IDA:MGI.
 GO:0005329; F:dopamine transmembrane transporter activity; IMP:MGI.
 GO:0005330; F:dopamine:sodium symporter activity; IEA:Compara.
 GO:0008144; F:drug binding; IEA:Compara.
 GO:0021984; P:adenohypophysis development; IMP:MGI.
 GO:0007568; P:aging; IEA:Compara.
 GO:0042416; P:dopamine biosynthetic process; IMP:MGI.
 GO:0042420; P:dopamine catabolic process; IMP:MGI.
 GO:0015872; P:dopamine transport; IMP:MGI.
 GO:0007595; P:lactation; IMP:MGI.
 GO:0007626; P:locomotory behavior; IMP:MGI.
 GO:0040018; P:positive regulation of multicellular organism growth; IMP:MGI.
 GO:0060134; P:prepulse inhibition; IMP:MGI.
 GO:0042053; P:regulation of dopamine metabolic process; IMP:MGI.
 GO:0051591; P:response to cAMP; IEA:Compara.
 GO:0042220; P:response to cocaine; IDA:MGI.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0045471; P:response to ethanol; IEA:Compara.
 GO:0010039; P:response to iron ion; IEA:Compara.
 GO:0035094; P:response to nicotine; IEA:Compara.
 GO:0007608; P:sensory perception of smell; IMP:MGI. 

Interpro

 IPR000175; Na/ntran_symport.
 IPR002436; Na/ntran_symport_dopamine. 

Pfam

 PF00209; SNF 

SMART

  

PROSITE

 PS00610; NA_NEUROTRAN_SYMP_1
 PS00754; NA_NEUROTRAN_SYMP_2
 PS50267; NA_NEUROTRAN_SYMP_3 

PRINTS

 PR01202; DOPTRANSPORT.
 PR00176; NANEUSMPORT.