CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-003722
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Serine protease 56 
Protein Synonyms/Alias
  
Gene Name
 PRSS56 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
318DGCGEPGKPGVYTRVubiquitination[1]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
 Serine protease required during eye development. 
Sequence Annotation
 DOMAIN 105 337 Peptidase S1.
 ACT_SITE 145 145 Charge relay system (By similarity).
 ACT_SITE 191 191 Charge relay system (By similarity).
 ACT_SITE 286 286 Charge relay system (By similarity).
 CARBOHYD 97 97 N-linked (GlcNAc...) (Potential).
 DISULFID 130 146 By similarity.
 DISULFID 225 292 By similarity.
 DISULFID 256 271 By similarity.
 DISULFID 282 313 By similarity.  
Keyword
 Complete proteome; Disease mutation; Disulfide bond; Glycoprotein; Hydrolase; Microphthalmia; Protease; Reference proteome; Serine protease; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 603 AA 
Protein Sequence
MLLAVLLLLP LPSSWFAHGH PLYTRLPPSA LQVLSAQGTQ ALQAAQRSAQ WAINRVAMEI 60
QHRSHECRGS GRPRPQALLQ DPPEPGPCGE RRPSTANVTR AHGRIVGGSA APPGAWPWLV 120
RLQLGGQPLC GGVLVAASWV LTAAHCFVGA PNELLWTVTL AEGSRGEQAE EVPVNRILPH 180
PKFDPRTFHN DLALVQLWTP VSPGGSARPV CLPQEPQEPP AGTACAIAGW GALFEDGPEA 240
EAVREARVPL LSTDTCRRAL GPGLRPSTML CAGYLAGGVD SCQGDSGGPL TCSEPGPRPR 300
EVLFGVTSWG DGCGEPGKPG VYTRVAVFKD WLQEQMSASS SREPSCRELL AWDPPQELQA 360
DAARLCAFYA RLCPGSQGAC ARLAHQQCLQ RRRRCELRSL AHTLLGLLRN AQELLGPRPG 420
LRRLAPALAL PAPALRESPL HPARELRLHS GSRAAGTRFP KRRPEPRGEA NGCPGLEPLR 480
QKLAALQGAH AWILQVPSEH LAMNFHEVLA DLGSKTLTGL FRAWVRAGLG GRHVAFSGLV 540
GLEPATLARS LPRLLVQALQ AFRVAALAEG EPEGPWMDVG QGPGLERKGH HPLNPQVPPA 600
RQP 603 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
 GO:0004252; F:serine-type endopeptidase activity; ISS:UniProtKB.
 GO:0043010; P:camera-type eye development; IMP:UniProtKB.
 GO:0006508; P:proteolysis; ISS:UniProtKB. 
Interpro
 IPR001254; Peptidase_S1.
 IPR018114; Peptidase_S1_AS.
 IPR001314; Peptidase_S1A.
 IPR009003; Trypsin-like_Pept_dom. 
Pfam
 PF00089; Trypsin 
SMART
 SM00020; Tryp_SPc 
PROSITE
 PS50240; TRYPSIN_DOM
 PS00134; TRYPSIN_HIS
 PS00135; TRYPSIN_SER 
PRINTS
 PR00722; CHYMOTRYPSIN.