UniProt Accession

 PPA6_MOUSE; Q8BP40; Q3TNE2; Q8BN33; Q9JMG5; Q9QXG5 

Genbank Protein ID

 AB030038; AK077729; AK089736; AK160271; AK165356; AK171757; BC047276; AF216223 

Genbank Nucleotide ID

 BAA94308.1; BAC36983.1; BAC40949.1; BAE35722.1; BAE38147.1; BAE42654.1; AAH47276.1; AAF20010.1 

Protein Name

 Lysophosphatidic acid phosphatase type 6 

Protein Synonyms/Alias

 Acid phosphatase 6, lysophosphatidic; Acid phosphatase-like protein 1; PACPL1 

Gene Name

 Acp6 

Gene Synonyms/Alias

 Acpl1; Lpap 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
212	EKTRGRKKAAISQPG	ubiquitination	[1]
316	DPTTAPSKTRKMYLY	acetylation	[2]
316	DPTTAPSKTRKMYLY	succinylation	[2]
389	DKLCPLDKFLNTMSV	acetylation	[3]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Hydrolyzes lysophosphatidic acid to monoacylglycerol (By similarity). 

Sequence Annotation

 ACT_SITE 52 52 Nucleophile (By similarity).
 ACT_SITE 327 327 Proton donor (By similarity).  

Keyword

 Alternative splicing; Complete proteome; Hydrolase; Reference proteome; Secreted; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 418 AA 

Protein Sequence

Gene Ontology

 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0003993; F:acid phosphatase activity; IEA:EC. 

Interpro

 IPR000560; His_Pase_superF_clade-2. 

Pfam

 PF00328; His_Phos_2 

SMART

  

PROSITE

 PS00616; HIS_ACID_PHOSPHAT_1
 PS00778; HIS_ACID_PHOSPHAT_2 

PRINTS