UniProt Accession

 SYT3_RAT; P40748; Q925B7 

Genbank Protein ID

 D28512; AF375464 

Genbank Nucleotide ID

 BAA05870.1; AAK56959.1 

Protein Name

 Synaptotagmin-3 

Protein Synonyms/Alias

 Synaptotagmin III; SytIII 

Gene Name

 Syt3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
273	AKLIGQIKPELYQGT	ubiquitination	[1]

Reference

 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. 

Sequence Annotation

 DOMAIN 299 400 C2 1.
 DOMAIN 431 534 C2 2.
 METAL 328 328 Calcium 1 (By similarity).
 METAL 328 328 Calcium 2 (By similarity).
 METAL 334 334 Calcium 1 (By similarity).
 METAL 386 386 Calcium 1 (By similarity).
 METAL 386 386 Calcium 2 (By similarity).
 METAL 387 387 Calcium 1; via carbonyl oxygen (By
 METAL 388 388 Calcium 1 (By similarity).
 METAL 388 388 Calcium 2 (By similarity).
 METAL 388 388 Calcium 3 (By similarity).
 METAL 391 391 Calcium 3 (By similarity).
 METAL 394 394 Calcium 2 (By similarity).
 METAL 394 394 Calcium 3 (By similarity).  

Keyword

 3D-structure; Calcium; Cell junction; Complete proteome; Cytoplasmic vesicle; Membrane; Metal-binding; Reference proteome; Repeat; Synapse; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 588 AA 

Protein Sequence

Gene Ontology

 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0005768; C:endosome; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0045202; C:synapse; NAS:RGD.
 GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0005509; F:calcium ion binding; TAS:RGD.
 GO:0005544; F:calcium-dependent phospholipid binding; IDA:RGD.
 GO:0030276; F:clathrin binding; IDA:BHF-UCL.
 GO:0001786; F:phosphatidylserine binding; IDA:RGD.
 GO:0019905; F:syntaxin binding; IDA:RGD.
 GO:0005215; F:transporter activity; IEA:InterPro.
 GO:0017156; P:calcium ion-dependent exocytosis; TAS:RGD.
 GO:0031340; P:positive regulation of vesicle fusion; IDA:RGD.
 GO:0051592; P:response to calcium ion; IDA:RGD.
 GO:0016079; P:synaptic vesicle exocytosis; TAS:RGD. 

Interpro

 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR020477; C2_dom.
 IPR018029; C2_membr_targeting.
 IPR001565; Synaptotagmin. 

Pfam

 PF00168; C2 

SMART

 SM00239; C2 

PROSITE

 PS50004; C2 

PRINTS

 PR00360; C2DOMAIN.
 PR00399; SYNAPTOTAGMN.