CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015036
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Trigger factor 
Protein Synonyms/Alias
 TF; PPIase 
Gene Name
 tig 
Gene Synonyms/Alias
 RPA2962 
Created Date
 July 27, 2013 
Organism
 Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009) 
NCBI Taxa ID
 258594 
Lysine Modification
Position
Peptide
Type
References
99ITMPQDQKEIEDILEacetylation[1]
421RAPIYEDKVVDFILEacetylation[1]
Reference
 [1] System-wide studies of N-lysine acetylation in Rhodopseudomonas palustris reveal substrate specificity of protein acetyltransferases.
 Crosby HA, Pelletier DA, Hurst GB, Escalante-Semerena JC.
 J Biol Chem. 2012 May 4;287(19):15590-601. [PMID: 22416131] 
Functional Description
 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase (By similarity). 
Sequence Annotation
 DOMAIN 171 256 PPIase FKBP-type.  
Keyword
 Cell cycle; Cell division; Chaperone; Complete proteome; Cytoplasm; Isomerase; Rotamase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 452 AA 
Protein Sequence
MQVKETVADG LKREFQVNVP AADIDAKIDE KLADLKDKVR LNGFRPGKVP TAHLKRVYGR 60
SVAAETIDKL VRDTNDGIFS ERGFRLATEP KITMPQDQKE IEDILEGKSD LTYTVAIEVV 120
PAIELADFKS FSVEKPVVDV ADSDVDEAIK RIADANRAYA DKAEGAKAET GDRVTVSFKG 180
TIDGVAFDGG TGEDIPVVIG SASFIPGFED QLVGIAVGET RTIKVTFPAN YASETLAGKP 240
AEFETTATKL EAPQETTIDD EFAKTLGLES LDKLKEAAKA RLAAEYAGAS RLKVKRQLLD 300
RLDEAHKFDA PPSLIEQEFE VMWRSINAEM QSTGKTFADE NTTEDAAKEE YRKIADRRVR 360
LGLVLSEIGE KNKIQVTDDE VSRAVIERAR QMPGREKEVW DFYRSNPEAL AQLRAPIYED 420
KVVDFILELA NVTEKKVTRE ELYKDEDDKT AA 452 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:HAMAP.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0006457; P:protein folding; IEA:HAMAP.
 GO:0000413; P:protein peptidyl-prolyl isomerization; IEA:GOC.
 GO:0015031; P:protein transport; IEA:HAMAP. 
Interpro
 IPR001179; PPIase_FKBP_dom.
 IPR005215; Trig_fac.
 IPR008880; Trigger_fac_C.
 IPR008881; Trigger_fac_ribosome-bd_bac.
 IPR027304; Trigger_fact/SurA_dom. 
Pfam
 PF00254; FKBP_C
 PF05698; Trigger_C
 PF05697; Trigger_N 
SMART
  
PROSITE
 PS50059; FKBP_PPIASE 
PRINTS