CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022831
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Peroxisome proliferator-activated receptor gamma coactivator 1-alpha 
Protein Synonyms/Alias
 PGC-1-alpha; PPAR-gamma coactivator 1-alpha; PPARGC-1-alpha; Ligand effect modulator 6 
Gene Name
 PPARGC1A 
Gene Synonyms/Alias
 LEM6; PGC1; PGC1A; PPARGC1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
79EPSNIFEKIDEENEAacetylation[1]
145AEEPSLLKKLLLAPAacetylation[1]
184RTNPAIVKTENSWSNacetylation[1, 2]
254QSQHLQAKPTTLSLPacetylation[1]
271PESPNDPKGSPFENKacetylation[1]
278KGSPFENKTIERTLSacetylation[1]
321PKLKSSCKTVVPPPSacetylation[1]
347QGNNSTKKGPEQSELacetylation[1]
413DSRQLENKDVSSDWQacetylation[1]
442RETLEASKQVSPCSTacetylation[1]
451VSPCSTRKQLQDQEIacetylation[1]
758CGRKQFFKSNYADLDacetylation[1]
779DPASTKSKYDSLDFDacetylation[1]
Reference
 [1] Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1.
 Rodgers JT, Lerin C, Haas W, Gygi SP, Spiegelman BM, Puigserver P.
 Nature. 2005 Mar 3;434(7029):113-8. [PMID: 15744310]
 [2] SUMOylation attenuates the function of PGC-1alpha.
 Rytinki MM, Palvimo JJ.
 J Biol Chem. 2009 Sep 18;284(38):26184-93. [PMID: 19625249] 
Functional Description
 Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. 
Sequence Annotation
 DOMAIN 677 753 RRM.
 REGION 293 339 Interaction with PPARG.
 MOTIF 144 148 LXXLL motif.
 MOD_RES 79 79 N6-acetyllysine (By similarity).
 MOD_RES 146 146 N6-acetyllysine (By similarity).
 MOD_RES 178 178 Phosphothreonine; by AMPK (By
 MOD_RES 184 184 N6-acetyllysine (By similarity).
 MOD_RES 254 254 N6-acetyllysine (By similarity).
 MOD_RES 271 271 N6-acetyllysine (By similarity).
 MOD_RES 278 278 N6-acetyllysine (By similarity).
 MOD_RES 321 321 N6-acetyllysine (By similarity).
 MOD_RES 347 347 N6-acetyllysine (By similarity).
 MOD_RES 413 413 N6-acetyllysine (By similarity).
 MOD_RES 442 442 N6-acetyllysine (By similarity).
 MOD_RES 451 451 N6-acetyllysine (By similarity).
 MOD_RES 539 539 Phosphoserine; by AMPK (By similarity).
 MOD_RES 758 758 N6-acetyllysine (By similarity).
 MOD_RES 779 779 N6-acetyllysine (By similarity).  
Keyword
 3D-structure; Acetylation; Activator; Complete proteome; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; RNA-binding; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 798 AA 
Protein Sequence
MAWDMCNQDS ESVWSDIECA ALVGEDQPLC PDLPELDLSE LDVNDLDTDS FLGGLKWCSD 60
QSEIISNQYN NEPSNIFEKI DEENEANLLA VLTETLDSLP VDEDGLPSFD ALTDGDVTTD 120
NEASPSSMPD GTPPPQEAEE PSLLKKLLLA PANTQLSYNE CSGLSTQNHA NHNHRIRTNP 180
AIVKTENSWS NKAKSICQQQ KPQRRPCSEL LKYLTTNDDP PHTKPTENRN SSRDKCTSKK 240
KSHTQSQSQH LQAKPTTLSL PLTPESPNDP KGSPFENKTI ERTLSVELSG TAGLTPPTTP 300
PHKANQDNPF RASPKLKSSC KTVVPPPSKK PRYSESSGTQ GNNSTKKGPE QSELYAQLSK 360
SSVLTGGHEE RKTKRPSLRL FGDHDYCQSI NSKTEILINI SQELQDSRQL ENKDVSSDWQ 420
GQICSSTDSD QCYLRETLEA SKQVSPCSTR KQLQDQEIRA ELNKHFGHPS QAVFDDEADK 480
TGELRDSDFS NEQFSKLPMF INSGLAMDGL FDDSEDESDK LSYPWDGTQS YSLFNVSPSC 540
SSFNSPCRDS VSPPKSLFSQ RPQRMRSRSR SFSRHRSCSR SPYSRSRSRS PGSRSSSRSC 600
YYYESSHYRH RTHRNSPLYV RSRSRSPYSR RPRYDSYEEY QHERLKREEY RREYEKRESE 660
RAKQRERQRQ KAIEERRVIY VGKIRPDTTR TELRDRFEVF GEIEECTVNL RDDGDSYGFI 720
TYRYTCDAFA ALENGYTLRR SNETDFELYF CGRKQFFKSN YADLDSNSDD FDPASTKSKY 780
DSLDFDSLLK EAQRSLRR 798 
Gene Ontology
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005665; C:DNA-directed RNA polymerase II, core complex; TAS:UniProtKB.
 GO:0016605; C:PML body; IEA:UniProtKB-SubCell.
 GO:0050681; F:androgen receptor binding; NAS:UniProtKB.
 GO:0031490; F:chromatin DNA binding; ISS:UniProtKB.
 GO:0030374; F:ligand-dependent nuclear receptor transcription coactivator activity; IDA:BHF-UCL.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; TAS:UniProtKB.
 GO:0001104; F:RNA polymerase II transcription cofactor activity; TAS:UniProtKB.
 GO:0008134; F:transcription factor binding; TAS:UniProtKB.
 GO:0030521; P:androgen receptor signaling pathway; NAS:UniProtKB.
 GO:0050873; P:brown fat cell differentiation; TAS:UniProtKB.
 GO:0001678; P:cellular glucose homeostasis; NAS:UniProtKB.
 GO:0034599; P:cellular response to oxidative stress; ISS:UniProtKB.
 GO:0007586; P:digestion; TAS:UniProtKB.
 GO:0019395; P:fatty acid oxidation; NAS:UniProtKB.
 GO:0006094; P:gluconeogenesis; NAS:UniProtKB.
 GO:0007005; P:mitochondrion organization; NAS:UniProtKB.
 GO:0006397; P:mRNA processing; TAS:UniProtKB.
 GO:0043524; P:negative regulation of neuron apoptotic process; ISS:UniProtKB.
 GO:0070997; P:neuron death; IDA:UniProtKB.
 GO:2001171; P:positive regulation of ATP biosynthetic process; ISS:UniProtKB.
 GO:2000507; P:positive regulation of energy homeostasis; ISS:UniProtKB.
 GO:0046321; P:positive regulation of fatty acid oxidation; TAS:UniProtKB.
 GO:0045722; P:positive regulation of gluconeogenesis; TAS:UniProtKB.
 GO:0035066; P:positive regulation of histone acetylation; TAS:UniProtKB.
 GO:0010822; P:positive regulation of mitochondrion organization; ISS:UniProtKB.
 GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IDA:BHF-UCL.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:BHF-UCL.
 GO:0006461; P:protein complex assembly; TAS:UniProtKB.
 GO:0050821; P:protein stabilization; TAS:UniProtKB.
 GO:2000310; P:regulation of N-methyl-D-aspartate selective glutamate receptor activity; IEA:Compara.
 GO:0022904; P:respiratory electron transport chain; ISS:UniProtKB.
 GO:0001666; P:response to hypoxia; IEA:Compara.
 GO:0014850; P:response to muscle activity; ISS:BHF-UCL.
 GO:0042594; P:response to starvation; NAS:UniProtKB.
 GO:0008380; P:RNA splicing; TAS:UniProtKB.
 GO:0001659; P:temperature homeostasis; TAS:UniProtKB.
 GO:0006367; P:transcription initiation from RNA polymerase II promoter; TAS:UniProtKB. 
Interpro
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 
Pfam
 PF00076; RRM_1 
SMART
 SM00360; RRM 
PROSITE
 PS50102; RRM 
PRINTS