CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033857
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 5-formyltetrahydrofolate cyclo-ligase 
Protein Synonyms/Alias
  
Gene Name
 Mthfs 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
93GNRLGRGKGYYDTYLacetylation[1]
93GNRLGRGKGYYDTYLsuccinylation[1]
101GYYDTYLKRCVQHQEacetylation[2, 3, 4]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [3] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [4] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 146 AA 
Protein Sequence
MQDEVETEVI IKDIFKQGKI CFIPRYQFQS NHMDMVRLTS SEEIALLPKT SWNIHQPGEG 60
DVREEALSTG GLDLIFLPGL GFDKDGNRLG RGKGYYDTYL KRCVQHQEVK PYTMALAFKE 120
QICPQIPVDE HDMKVDEVLY EDSPAS 146 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0030272; F:5-formyltetrahydrofolate cyclo-ligase activity; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro. 
Interpro
 IPR002698; FTHF_cligase.
 IPR024185; FTHF_cligase-like. 
Pfam
 PF01812; 5-FTHF_cyc-lig 
SMART
  
PROSITE
  
PRINTS