CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033338
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Thyroid adenoma-associated protein 
Protein Synonyms/Alias
  
Gene Name
 THADA 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
412ESSQVLYKLEQSKSKubiquitination[1]
428EPENELTKQHPSVSLubiquitination[1]
718NDYFNQAKILKEHDSubiquitination[1, 2, 3, 4]
721FNQAKILKEHDSFDMubiquitination[3, 4]
729EHDSFDMKDLNASVVubiquitination[4]
864KCSDPSSKLCATRRSubiquitination[3, 5, 6]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [6] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1097 AA 
Protein Sequence
MSSCRSLCCG DISQSAVLFL CQGTLAMLDW QNGSMGRSGE ALLLDTAHVL FTLSSQIKEP 60
TLEMFLSRIL ASWTNSAIQV LESSSPSLTD SLNGNSSIVG RLLEYVYTHW EHPLDALRHQ 120
TKIMFKNLLQ MHRLTVEGAD FVPDPFFVEL TESLLRLEWH IKGKYTCLGC LVECIGVEHI 180
LAIDKTIPSQ ILEVMGDQSL VPYASDLLET MFRNHKSHLK SQTAESSWID QWHETWVSPL 240
LFILCEGNLD QKSYVIDYYL PKLLSYSPES LQYMVKILQT SIDAKTGQEQ SFPSLGSCNS 300
RGALGALMAC LRIARAHGHL QSATDTWENL VSDARIKQGL IHQHCQVRID TLGLLCESNR 360
STEIVSMEEM QWIQFFITYN LNSQSPGVRQ QICSLLKKLF CRIQESSQVL YKLEQSKSKR 420
EPENELTKQH PSVSLQQYKN FMSSICNSLF EALFPGSSYS TRFSALTILG SIAEVFHVPE 480
GRIYTVYQLS HDIDVGRFQT LMECFTSTFE DVKILAFDLL MKLSKTAVHF QDSGKLQGLF 540
QAALELSTST KPYDCVTASY LLNFLIWQDA LPSSLSAYLT QQVACDNGDR PAAVVERNTL 600
MVIKCLMENL EEEVSQAENS LLQAAAAFPM YGRVHCITGA LQKLSLNSLQ LVSEWRPVVE 660
KLLLMSYRLS TVVSPVIQSS SPEGLIPMDT DSESASRLQM ILNEIQPRDT NDYFNQAKIL 720
KEHDSFDMKD LNASVVNIDT STEIKGKEVK TCDVTAQMVL VCCWRSMKEV ALLLGMLCQL 780
LPMQPVPESS DGLLTVEQVK EIGDYFKQHL LQSRHRGAFE LAYTGFVKLT EVLNRCPNVS 840
LQKLPEQWLW SVLEEIKCSD PSSKLCATRR SAGIPFYIQA LLASEPKKGR MDLLKITMKE 900
LISLAGPTDD IQSTVPQVHA LNILRALFRD TRLGENIIPY VADGAKAAIL GFTSPVWAVR 960
NSSTLLFSAL ITRIFGVKRA KDEHSKTNRM TGREFFSRFP ELYPFLLKQL ETVANTVDSD 1020
MGEPNRHPSM FLLLLVLERL YASPMDGTSS ALSMGPFVPF IMRVLLCCPG WSAVARSQLT 1080
ATSTSWVQAI LLPQPPE 1097 
Gene Ontology
  
Interpro
 IPR016024; ARM-type_fold.
 IPR019442; DUF2428_death-receptor-like. 
Pfam
 PF10350; DUF2428 
SMART
  
PROSITE
  
PRINTS