UniProt Accession

 GSTK1_HUMAN; Q9Y2Q3; B4DIH1; B4DSY2; Q6P4H0; Q7Z520; Q9P1S4 

Genbank Protein ID

 AY520571; AY486465; AF070657; AF068287; AF087849; AL136938; AK289570; AK295592; AK299968; AC073342; CH471198; BC001231; BC050715; BC063425 

Genbank Nucleotide ID

 AAS00610.1; AAS01180.1; AAD20963.1; AAF65506.1; AAP97160.1; CAB66872.1; BAF82259.1; BAG58483.1; BAG61794.1; EAW51877.1; AAH01231.1; AAH50715.1; AAH63425.1 

Protein Name

 Glutathione S-transferase kappa 1 

Protein Synonyms/Alias

 GST 13-13; GST class-kappa; GSTK1-1; hGSTK1; Glutathione S-transferase subunit 13 

Gene Name

 GSTK1 

Gene Synonyms/Alias

 HDCMD47P 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
71	LYMANDLKLLRHHLQ	ubiquitination	[1, 2]
116	EHPEMLEKASRELWM	ubiquitination	[3]
214	QAQGLLEKIATPKVK	ubiquitination	[3]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Significant glutathione conjugating activity is found only with the model substrate, 1-chloro-2,4-dinitrobenzene (CDNB). 

Sequence Annotation

 REGION 16 18 Glutathione binding.
 REGION 200 201 Glutathione binding.
 BINDING 53 53 Glutathione.
 BINDING 183 183 Glutathione; via amide nitrogen and
 MOD_RES 71 71 N6-acetyllysine.
 MOD_RES 169 169 N6-acetyllysine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Peroxisome; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 226 AA 

Protein Sequence

Gene Ontology

 GO:0005743; C:mitochondrial inner membrane; IEA:Compara.
 GO:0005759; C:mitochondrial matrix; IEA:Compara.
 GO:0005777; C:peroxisome; IDA:UniProtKB.
 GO:0004602; F:glutathione peroxidase activity; IDA:UniProtKB.
 GO:0004364; F:glutathione transferase activity; IDA:UniProtKB.
 GO:0015035; F:protein disulfide oxidoreductase activity; IEA:InterPro.
 GO:0006749; P:glutathione metabolic process; IEA:Compara. 

Interpro

 IPR001853; DSBA-like_thioredoxin_dom.
 IPR014440; HCCAis_GSTk.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF01323; DSBA 

SMART

  

PROSITE

  

PRINTS