UniProt Accession

 SEP15_HUMAN; O60613; Q4GZG7; Q8WU00; Q9BS64; Q9GZW0; Q9NR01 

Genbank Protein ID

 AF051894; AF288991; AF288992; AF267982; AL833575; AL121989; BC005294; BC016359; BC021697 

Genbank Nucleotide ID

 AAC15478.1; AAG31556.1; AAG31557.1; AAF78966.1; CAJ18323.1; CAC04186.1; AAH05294.3; AAH16359.3; AAH21697.3 

Protein Name

 15 kDa selenoprotein 

Protein Synonyms/Alias

  

Gene Name

 SEP15 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
80	EEAQFETKKLYAGAI	ubiquitination	[1, 2]
81	EAQFETKKLYAGAIL	ubiquitination	[2]
119	LFRGLQIKYVRGSDP	ubiquitination	[2]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 May be involved in redox reactions associated with the formation of disulfide bonds. May contribute to the quality control of protein folding in the endoplasmic reticulum (By similarity). 

Sequence Annotation

  

Keyword

 Alternative splicing; Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Reference proteome; Selenocysteine; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 162 AA 

Protein Sequence

Gene Ontology

 GO:0005788; C:endoplasmic reticulum lumen; IDA:UniProtKB.
 GO:0008430; F:selenium binding; IDA:UniProtKB.
 GO:0051084; P:'de novo' posttranslational protein folding; TAS:UniProtKB. 

Interpro

 IPR014912; Sep15_SelM.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF08806; Sep15_SelM 

SMART

  

PROSITE

  

PRINTS