CPLM-017899

Genbank Nucleotide ID

Cell adhesion molecule 1

Protein Synonyms/Alias

Immunoglobulin superfamily member 4; IgSF4; Nectin-like protein 2; NECL-2; Spermatogenic immunoglobulin superfamily; SgIgSF; Synaptic cell adhesion molecule; SynCAM; Tumor suppressor in lung cancer 1; TSLC-1

Igsf4; Necl2; Ra175; Syncam; SynCam1; Tslc1

Mus musculus (Mouse)

Position	Peptide	Type	References
451	GQNNSEEKKEYFI**	ubiquitination	[1]

[1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]

Functional Description

Mediates homophilic cell-cell adhesion in a Ca(2+)- independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.

DOMAIN 48 142 Ig-like V-type.
DOMAIN 147 241 Ig-like C2-type 1.
DOMAIN 246 332 Ig-like C2-type 2.
MOD_RES 448 448 Phosphoserine.
CARBOHYD 70 70 N-linked (GlcNAc...).
CARBOHYD 104 104 N-linked (GlcNAc...).
CARBOHYD 116 116 N-linked (GlcNAc...).
CARBOHYD 168 168 N-linked (GlcNAc...).
CARBOHYD 304 304 N-linked (GlcNAc...); atypical.
CARBOHYD 307 307 N-linked (GlcNAc...).
CARBOHYD 311 311 N-linked (GlcNAc...).
DISULFID 67 127 By similarity.
DISULFID 169 223 By similarity.
DISULFID 270 316 By similarity.

Alternative splicing; Apoptosis; Cell adhesion; Cell junction; Cell membrane; Complete proteome; Developmental protein; Differentiation; Disulfide bond; Glycoprotein; Immunity; Immunoglobulin domain; Membrane; Phosphoprotein; Reference proteome; Repeat; Signal; Spermatogenesis; Synapse; Transmembrane; Transmembrane helix; Tumor suppressor.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0030424; C:axon; IDA:MGI.
GO:0016323; C:basolateral plasma membrane; IDA:UniProtKB.
GO:0005911; C:cell-cell junction; IDA:UniProtKB.
GO:0030425; C:dendrite; IDA:MGI.
GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0008021; C:synaptic vesicle; IDA:MGI.
GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO:0060348; P:bone development; IMP:MGI.
GO:0007420; P:brain development; IEA:Compara.
GO:0016338; P:calcium-independent cell-cell adhesion; IDA:MGI.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
GO:0008037; P:cell recognition; IDA:UniProtKB.
GO:0051606; P:detection of stimulus; IDA:UniProtKB.
GO:0007157; P:heterophilic cell-cell adhesion; IDA:UniProtKB.
GO:0007156; P:homophilic cell adhesion; IDA:UniProtKB.
GO:0001889; P:liver development; IEA:Compara.
GO:0050715; P:positive regulation of cytokine secretion; IEA:Compara.
GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
GO:0042271; P:susceptibility to natural killer cell mediated cytotoxicity; IDA:UniProtKB.
GO:0007416; P:synapse assembly; IDA:MGI.
GO:0009826; P:unidimensional cell growth; IMP:MGI.

IPR013162; CD80_C2-set.
IPR007110; Ig-like_dom.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR013106; Ig_V-set.
IPR003585; Neurexin-like.

PF08205; C2-set_2
PF07686; V-set

SM00294; 4.1m
SM00409; IG
SM00408; IGc2