CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016754
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Myelin expression factor 2 
Protein Synonyms/Alias
 MEF-2; MyEF-2 
Gene Name
 Myef2 
Gene Synonyms/Alias
 Kiaa1341; Mef2 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
108DMKWQAIKDLMREKVubiquitination[1]
529PFDLTWQKLKEKFSQubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Transcriptional repressor of the myelin basic protein gene (MBP). Binds to the proximal MB1 element 5'-TTGTCC-3' of the MBP promoter. Its binding to MB1 and function are inhibited by PURA. 
Sequence Annotation
 DOMAIN 91 169 RRM 1.
 DOMAIN 224 301 RRM 2.
 DOMAIN 514 590 RRM 3.
 MOD_RES 422 422 Phosphoserine (By similarity).  
Keyword
 Alternative splicing; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; RNA-binding; Transcription. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 591 AA 
Protein Sequence
MADADKSEAA AGDDGSQQQP AEPRRDTHPG EPEKPPRSSA NGVKMENDES VKEEKSDLKE 60
KSTGNKKANR FHPYSKDKNS GTGEKKGPNR NRVFISNIPY DMKWQAIKDL MREKVGEVTY 120
VELFKDAEGK SRGCGVVEFK DEEFVKKALE TMNKYDLSGR PLNIKEDPDG ENARRALQRT 180
GTSFQGSHAS DVGSGLVNLP PSILNNPNIP PEVISNLQAG RLGSTIFVAN LDFKVGWKKL 240
KEVFSIAGTV KRADIKEDKD GKSRGMGTVT FEQAIEAVQA ISMFNGQFLF DRPMHVKMDD 300
KSVPHEDYRS HDSKTSQLPR GLGGIGMGLG PGGQPISASQ LNITGVMGNL GPSGMGMDGP 360
GFGGVNRIGG GVGFGGLEAM NSMAGFGGVG RMGELYRGAM TSSMERDFGR GDIGLSRGFG 420
DSFGRLGSAM IGGFAGRIGA SNMGPVGTGI SGSMSGMSTV TGGMGMGLDR MSSSFDRMGP 480
GIGAILERSI DVDRGFLSGP MGSGMRDRLG SKGNQIFVRN LPFDLTWQKL KEKFSQCGHV 540
MFAEIKMENG KSKGCGTVRF ESAESAEKAC RIMNGIKISG REIDVRLDRN A 591 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 
Pfam
 PF00076; RRM_1 
SMART
 SM00360; RRM 
PROSITE
 PS50102; RRM 
PRINTS