UniProt Accession

 P90613_TOXGO; P90613; B6KJT2; B9PGJ8; B9Q4R1 

Genbank Protein ID

 U35118; DS984734; EQ967475; EQ970680 

Genbank Nucleotide ID

 AAC47443.1; EEB00965.1; EEE26845.1; EEE34698.1 

Protein Name

 Lactate dehydrogenase 

Protein Synonyms/Alias

 Lactate dehydrogenase, putative 

Gene Name

 TGGT1_115280, TGME49_032350, TGVEG_023290 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Toxoplasma gondii 

NCBI Taxa ID

 5811 

Lysine Modification

Position	Peptide	Type	References
120	REIGQNIKKYCPKTF	acetylation	[1]
125	NIKKYCPKTFIIVVT	acetylation	[1]
308	ELNEEEKKQFQKSVD	acetylation	[1]
312	EEKKQFQKSVDDVMA	acetylation	[1]

Reference

 [1] Protein intrinsic disorder in the acetylome of intracellular and extracellular Toxoplasma gondii.
 Xue B, Jeffers V, Sullivan WJ, Uversky VN.
 Mol Biosyst. 2013 Apr 5;9(4):645-57. [PMID: 23403842] 

Functional Description

  

Sequence Annotation

 NP_BIND 19 20 NAD.
 NP_BIND 87 88 NAD.
 NP_BIND 131 133 NAD.
 BINDING 40 40 NAD.
 BINDING 101 101 4-hydroxy-1,2,5-oxadizole-3-carboxylic
 BINDING 101 101 Oxalic acid.
 BINDING 101 101 Sulfate.
 BINDING 133 133 4-hydroxy-1,2,5-oxadizole-3-carboxylic
 BINDING 133 133 Oxalic acid.
 BINDING 156 156 NAD; via carbonyl oxygen.
 BINDING 164 164 4-hydroxy-1,2,5-oxadizole-3-carboxylic
 BINDING 164 164 Oxalic acid.
 BINDING 164 164 Sulfate.
 BINDING 188 188 4-hydroxy-1,2,5-oxadizole-3-carboxylic
 BINDING 188 188 NAD.
 BINDING 188 188 Oxalic acid.
 BINDING 188 188 Sulfate.
 BINDING 242 242 4-hydroxy-1,2,5-oxadizole-3-carboxylic  

Keyword

 3D-structure; Complete proteome; NAD; Nucleotide-binding; Oxidoreductase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 329 AA 

Protein Sequence

Gene Ontology

 GO:0004459; F:L-lactate dehydrogenase activity; IEA:EC.
 GO:0030060; F:L-malate dehydrogenase activity; IEA:InterPro.
 GO:0044262; P:cellular carbohydrate metabolic process; IEA:InterPro.
 GO:0006108; P:malate metabolic process; IEA:InterPro. 

Interpro

 IPR001557; L-lactate/malate_DH.
 IPR022383; Lactate/malate_DH_C.
 IPR001236; Lactate/malate_DH_N.
 IPR015955; Lactate_DH/Glyco_Ohase_4_C.
 IPR011275; Malate_DH_type3.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF02866; Ldh_1_C
 PF00056; Ldh_1_N 

SMART

  

PROSITE

  

PRINTS

 PR00086; LLDHDRGNASE.