CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018258
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
 CAG30298.1; BAC86253.1; AAD12228.1; CAI17954.1; CAI17954.1; CAI17954.1; CAI17954.1; CAI17954.1; CAI17954.1; CAI17954.1; CAI18761.1; CAI18761.1; CAI18761.1; CAI18761.1; CAI18761.1; CAI18761.1; CAI18761.1; CAI22357.1; CAI22357.1; CAI22357.1; CAI22357.1; CAI22357.1; CAI22357.1; CAI22357.1; CAI23583.1; CAI23583.1; CAI23583.1; CAI23583.1; CAI23583.1; CAI23583.1; CAI23583.1; CAI23588.1; CAI23588.1; CAI23588.1; CAI23588.1; CAI23588.1; CAI23588.1; CAI23588.1; CAQ07922.1; CAQ07922.1; CAQ07922.1; CAQ07922.1; CAQ07922.1; CAQ07922.1; CAQ07922.1; CAQ09326.1; CAQ09326.1; CAQ09326.1; CAQ09326.1; CAQ09326.1; CAQ09326.1; CAQ09326.1; CAQ09531.1; CAQ09531.1; CAQ09531.1; CAQ09531.1; CAQ09531.1; CAQ09531.1; CAQ09531.1; CAQ10969.1; CAQ10969.1; CAQ10969.1; CAQ10969.1; CAQ10969.1; CAQ10969.1; CAQ10969.1; CAQ11024.1; CAQ11024.1; CAQ11024.1; CAQ11024.1; CAQ11024.1; CAQ11024.1; CAQ11024.1; AAH01292.2; AAH02743.2; AAH20976.2; AAH29897.1; CAB46628.1 
Protein Name
 TBC1 domain family member 22A 
Protein Synonyms/Alias
  
Gene Name
 TBC1D22A 
Gene Synonyms/Alias
 C22orf4 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
12GARKQFWKRSNSKLPubiquitination[1]
202ASRLDKFKQLLAGPNubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 May act as a GTPase-activating protein for Rab family protein(s) (By similarity). 
Sequence Annotation
 DOMAIN 222 446 Rab-GAP TBC.  
Keyword
 3D-structure; Alternative splicing; Complete proteome; GTPase activation; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 517 AA 
Protein Sequence
MASDGARKQF WKRSNSKLPG SIQHVYGAQH PPFDPLLHGT LLRSTAKMPT TPVKAKRVST 60
FQEFESNTSD AWDAGEDDDE LLAMAAESLN SEVVMETANR VLRNHSQRQG RPTLQEGPGL 120
QQKPRPEAEP PSPPSGDLRL VKSVSESHTS CPAESASDAA PLQRSQSLPH SATVTLGGTS 180
DPSTLSSSAL SEREASRLDK FKQLLAGPNT DLEELRRLSW SGIPKPVRPM TWKLLSGYLP 240
ANVDRRPATL QRKQKEYFAF IEHYYDSRND EVHQDTYRQI HIDIPRMSPE ALILQPKVTE 300
IFERILFIWA IRHPASGYVQ GINDLVTPFF VVFICEYIEA EEVDTVDVSG VPAEVLCNIE 360
ADTYWCMSKL LDGIQDNYTF AQPGIQMKVK MLEELVSRID EQVHRHLDQH EVRYLQFAFR 420
WMNNLLMREV PLRCTIRLWD TYQSEPDGFS HFHLYVCAAF LVRWRKEILE EKDFQELLLF 480
LQNLPTAHWD DEDISLLLAE AYRLKFAFAD APNHYKK 517 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
 GO:0005097; F:Rab GTPase activator activity; IEA:InterPro.
 GO:0032851; P:positive regulation of Rab GTPase activity; IEA:GOC. 
Interpro
 IPR000195; Rab-GTPase-TBC_dom. 
Pfam
 PF00566; RabGAP-TBC 
SMART
 SM00164; TBC 
PROSITE
 PS50086; TBC_RABGAP 
PRINTS