| Tag | Content |
|---|
| CPLM ID | CPLM-013245 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Inhibitor of growth protein 3 |
Protein Synonyms/Alias | |
Gene Name | Ing3 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 164 | ATDHIPEKKFKSEAL | acetylation | [1] | | 264 | NNDFQLGKEFSMPRE | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage (By similarity). |
Sequence Annotation | ZN_FING 363 412 PHD-type.
BINDING 365 365 Histone H3K4me3 (By similarity).
BINDING 376 376 Histone H3K4me3 (By similarity).
BINDING 380 380 Histone H3K4me3 (By similarity).
BINDING 388 388 Histone H3K4me3 (By similarity).
MOD_RES 264 264 N6-acetyllysine (By similarity). |
Keyword | Acetylation; Chromatin regulator; Complete proteome; Growth regulation; Metal-binding; Nucleus; Reference proteome; Transcription; Transcription regulation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 421 AA |
Protein Sequence | MLYLEDYLEM IEQLPMDLRD RFTEMREMDL QVQNAMDQLE QRVSEFFMNA KKNKPEWREE 60
QMASIKKDYY KALEDADEKV QLANQIYDLV DRHLRKLDQE LAKFKMELEA DNAGITEILE 120
RRSLELDAPS QPVNNHHAHS HTPVEKRKYN PTSHHTATDH IPEKKFKSEA LLSTLTSDAS 180
KENTLGCRNN NSTASCNNAY NVNSSQPLAS YNIGSLSSGA GAGAITMAAA QAVQATAQMK 240
EGRRTSSLKA SYEAFKNNDF QLGKEFSMPR ETAGYSSSSA LMTTLTQNAS SSAADSRSGR 300
KSKNNTKSSS QQSSSSSSSS SSSSLSLCSS SSTVVQEVSQ QTTVVPESDS NSQVDWTYDP 360
NEPRYCICNQ VSYGEMVGCD NQDCPIEWFH YGCVGLTEAP KGKWFCPQCT AAMKRRGSRH 420
K 421 |
Gene Ontology | GO:0032777; C:Piccolo NuA4 histone acetyltransferase complex; ISS:UniProtKB. GO:0004402; F:histone acetyltransferase activity; IEA:Compara. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0043968; P:histone H2A acetylation; ISS:UniProtKB. GO:0043967; P:histone H4 acetylation; ISS:UniProtKB. GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB. GO:0040008; P:regulation of growth; IEA:UniProtKB-KW. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |